The Value of Dual-parametric Magnetic Resonance Combined With Regional Saturation Biopsy in Patients With Suspected Prostate Cancer

The Value of Dual-parametric Magnetic Resonance Combined With Regional Saturation Biopsy in Diagnostic Decision-making in Patients With Suspected Prostate cancer--a Single-center Prospective Randomized Controlled Study

The aim of this study was to investigate the value of dual-parameter magnetic resonance imaging(bpMRI) combined with regional saturation biopsy in the diagnosis of prostate cancer by means of a prospective randomized controlled study.

The main questions it aims to answer are:

Can bpMRI guide the timing of prostate puncture and avoid unnecessary prostate biopsy? Effectiveness of focal saturation biopsy versus systemic biopsy + targeted biopsy.

Inclusion Criteria:

1. Be 18 years of age or older.

2. Compliance with clinical guidelines for indications for prostate puncture:

   • suspicious prostate nodule detected on rectal palpation;
   • suspicious lesion detected by transrectal ultrasound or magnetic resonance;
   • tPSA > 10 ng/mL;
   • tPSA 4-10 ng/mL with f/t < 0.16 or PSAD > 0.15.

3. Complete sequence of bpMRI of the prostate at our institution;

Exclusion Criteria:

1. tPSA >50ng/mL;
2. Presence of contraindications to prostate puncture and inability to tolerate prostate puncture;
3. reatment with radiotherapy, chemotherapy and surgery before prostate puncture;
4. History of prostate cancer;
5. Prostate multiparametric magnetic resonance images of poor quality or some sequences are missing.