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The risk version of the MTNR1B gene (which codes for a melatonin receptor) has been associated with type II diabetes (T2D) and associated physiological markers. People with the risk version of the gene have reduced secretion of insulin when melatonin levels are high (between evening and morning) and impaired glucose tolerance when they eat late. Previous research suggests eating a protein enriched breakfast can improve glucose response. Therefore, the present study will investigate if the version of the MTNR1B gene that people have is associated with their glucose response after breakfast. Also, whether a protein enriched breakfast improves glucose response in participants with the risk version of the gene. Measures of glucose response collected over the two-week duration of the study will be compared between groups with the different versions of the gene. These findings can be used to provide personalised nutrition advice which may reduce the risk of T2D.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Protein enriched breakfast | Experimental |
| |
| High carbohydrate breakfast | Active Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Breakfast | Dietary Supplement | Breakfast in one condition will be high carbohydrate and in the other protein enriched |
|
| Measure | Description | Time Frame |
|---|---|---|
| Glucose response | Area under the curve | 120 minutes |
| Measure | Description | Time Frame |
|---|---|---|
| CGM metrics - mean glucose | mean glucose for 14 days measured using (FreeStyle Libre Pro iQ Continuous Glucose Monitoring System) | 14 days |
| CGM metrics - Time in range | Time in range for 14 day period (FreeStyle Libre Pro iQ Continuous Glucose Monitoring System) |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| St Mary's University | London | United Kingdom |
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| ID | Term |
|---|---|
| D044882 | Glucose Metabolism Disorders |
| ID | Term |
|---|---|
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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| ID | Term |
|---|---|
| D062408 | Breakfast |
| ID | Term |
|---|---|
| D062407 | Meals |
| D005502 | Food |
| D000066888 | Diet, Food, and Nutrition |
| D010829 | Physiological Phenomena |
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Breakfast condition - high carbohydrate or protein enriched
| 14 days |
| CGM metrics - glycaemic variability | glycaemic variability for 14 day period (FreeStyle Libre Pro iQ Continuous Glucose Monitoring System) | 14 days |
| D019602 |
| Food and Beverages |