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In this study, the investigators observed the long-term incidence rate of osteoporosis in patients who received Helicobacter pylori eradication and examined differences by age and sex.
In this study, the investigators observed the long-term incidence rate of osteoporosis in patients who received Helicobacter pylori eradication and examined differences by age and sex. In addition, the investigators will analyze the correlation between the incidence of osteoporosis by comparing confounding factors such as body mass index, steroid use, and proton pump inhibitor use as well as the eradication status of H. pylori.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Eradicated group | Helicobacter pylori eradication was successfully achieved. |
| |
| Non-eradicated group | Helicobacter pylori eradication was not successfully achieved. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| DEXA(Dual-Energy X-ray Absorptiometry) | Diagnostic Test | Followed for up to 20 years |
|
| Measure | Description | Time Frame |
|---|---|---|
| the incidence of new-onset osteoporosis | The patients were prospectively monitored until they either developed osteoporosis or reached the study endpoint in February 2023, whichever occurred first. |
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Inclusion Criteria:
ㆍPatients tested Helicobacter pylori status
Exclusion Criteria:
ㆍPatients aged < 20 years ㆍPatients with unknown Helicobacter pylori bone density status ㆍPatients with with a history of gastric cancer ㆍPatients with prior Helicobacter pylori eradication therapy ㆍPatients with a history of osteoporosis
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Patients tested Helicobacter pylori status in Seoul National University Bundang Hospital, from 2003 to 2023
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Seoul National University Bundang Hospital | Seongnam-si | Gyeonggi-do | 13620 | South Korea |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40820207 | Derived | Kim Y, Choi Y, Kim N, Jeon EB, Kong SH, Lee JH, Lee HK, Jun YK, Yoon H, Shin CM, Park YS, Lee DH, Ahn S. Preventive Effect of Helicobacter pylori Eradication on Osteoporosis in Females: A 20-Year Prospective Observational Cohort Study. Gut Liver. 2026 May 15;20(3):385-396. doi: 10.5009/gnl250164. Epub 2025 Aug 18. |
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| ID | Term |
|---|---|
| D010024 | Osteoporosis |
| ID | Term |
|---|---|
| D001851 | Bone Diseases, Metabolic |
| D001847 | Bone Diseases |
| D009140 | Musculoskeletal Diseases |
| D008659 | Metabolic Diseases |
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| ID | Term |
|---|---|
| D015502 | Absorptiometry, Photon |
| ID | Term |
|---|---|
| D011859 | Radiography |
| D003952 | Diagnostic Imaging |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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| D009750 |
| Nutritional and Metabolic Diseases |
| D003720 |
| Densitometry |
| D010783 | Photometry |
| D002623 | Chemistry Techniques, Analytical |
| D008919 | Investigative Techniques |