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Risks: The risks or discomforts to participants while taking part in this research include temporary distress or anxiety pr potentially feeling mild discomfort answering questions about your thoughts and feelings.
Benefits: As a result of taking part in this research, participants may experience improvements in mental health.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| CAST | Experimental | Computerized anxiety sensitivity treatment (CAST), which has been used by researchers already in many RCTs. This involves 30 minutes of psychoeducational video material delivered via computer presentation followed by 30 minutes of repeated interoceptive exposure practice exercises such as 60 seconds of breathing through a coffee straw, shaking head from side to side, and looking into a mirror. |
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| HET | Placebo Comparator | Developed as a 30-minute online intervention that provides education about physical health habits that can impact mental health, such as diet, exercise, and sleep. This intervention has been used in prior clinical trials to control for effects of general education, general coping techniques, and use of technology. Participants in past clinical trials have reported that HET is engaging and beneficial. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| CAST | Behavioral | CAST is a transdiagnostic cognitive behavioral therapy (CBT)-based protocol designed to address elevated AS, particularly the amplification of cognitive stress symptoms including perceived confusion and memory problems. CAST is a fully computerized, 1-hour intervention. CAST contains video animation and audio narration throughout, as well as interactive features (e.g., brief quizzes to promote comprehension). Procedures draw heavily on standard CBT techniques; AS, a core vulnerability for anxiety and depression is targeted using these procedures. In this study, participants complete CAST as a group alongside other participants. |
| Measure | Description | Time Frame |
|---|---|---|
| Anxiety Sensitivity Index-3 | 18 item self-report measure indexing anxiety sensitivity (Taylor et al., 2007). Scores range from 0-72 with higher scores indicating more severe anxiety sensitivity | Baseline through Month 1 follow up |
| PROMIS Anxiety Scale 8a | 8-item self-report measure indexing overall anxiety (Pilkonis et al., 2011). Scores range from 8 to 40 with higher scores reflecting worse anxiety symptoms. | Baseline through Month 1 Follow Up |
| PROMIS Depression Scale 8b | 8 item self-report measure indexing depressive symptoms (Polkonis et al., 2014). Scores range from 8-40 with higher scores reflecting worse depression symptoms. | Baseline through Month 1 Follow Up |
| Treatment Acceptability Questionnaire | 7-item self-report measure used in prior studies (Short et al., 2017). Scores range from 0-21 with higher scores indicating more favorable acceptability ratings. | Baseline through Month 1 follow up |
| Treatment Engagement Questionnaire | Participants were given two items assessing how frequently they: 1) thought about CAST content in the past month; 2) engaged in interoceptive exposure practice. | Month 1 Follow Up |
| Measure | Description | Time Frame |
|---|---|---|
| Intolerance of Uncertainty-12 | 12 item self-report measure indexing intolerance of uncertainty (Carleton et al., 2007). Scores range from 12-60 with higher scores reflecting worse intolerance of uncertainty. | Baseline through Month 1 follow up |
| Client Satisfaction Questionnaire |
| Measure | Description | Time Frame |
|---|---|---|
| Group likingness/closeness | Self-report measure assessing how close group members felt with other members of their group (adapted from Byrne et al., 1971) | Baseline |
| Berlin Numeracy Test | Brief measure of numerical ability (Cokely et al., 2011) with scores ranging from 0-4, higher scores indicate better numerical ability. |
Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Florida State University Psychology Clinic | Tallahassee | Florida | 32304 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40435564 | Derived | Schubert FT, Morabito DM, Schmidt NB. Examining the efficacy of the computerized anxiety sensitivity treatment in a guided, group format: A randomized controlled trial. Behav Res Ther. 2025 Aug;191:104785. doi: 10.1016/j.brat.2025.104785. Epub 2025 May 20. |
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Participants were randomized to one of two treatment conditions (active CAST or control HET) and did not receive the other intervention.
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| HET | Behavioral | The HET protocol covers standard healthy lifestyle behaviors as well as broad coping strategies to address stress. HET is a fully computerized 1-hour control condition focused on increasing healthy behaviors and decreasing unhealthy behaviors. Content includes healthy eating, hydration, sleep and rest, stress management as well as other healthy lifestyle tips. HET was administered in a group format for this study. |
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A modified version of the Client Satisfaction Questionnaire (CSQ) will be administered to assess treatment acceptability. Scores range from 8-32 with higher scores reflecting more favorable acceptability ratings. |
| Baseline through Month 1 Follow Up |
| Difficulties in Emotion Regulation Scale | 16 item self-report measure indexing emotional dysregulation (DERS-16, Bjureberg et al., 2016). Scores range from 16 to 80 with higher scores reflecting worse emotion regulation difficulties. | Baseline through Month 1 follow up |
| Baseline |