Prospective Analysis of Circulating Nucleosomes in Patients Receiving a First Line Treatment for a Non-Hodgkin Lymphoma

Prospective Analysis of Circulating Nucleosomes in Patients Receiving a First Line Treatment for a Non-Hodgkin Lymphoma

The goal of this study is to prospectively follow the level of circulating nucleosomes in patients treated for a non-Hodgkin lymphoma and determine whether it correlates with the clinical response.

Inclusion Criteria:

• Histologically proven diagnosis of diffuse large B cell lymphoma or follicular lymphoma, according to the WHO 2016 classification, requiring a first line of treatment with a RCHOP 21 regimen
• Agreement to participate after receiving oral and written information on the study

Exclusion Criteria:

• History of previous treatment for lymphoma (excluding localized low dose radiotherapy in the case of follicular lymphoma)
• Treatment with a chemotherapy regimen different from RCHOP21