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This retrospective cohort study was conducted by reviewing the records of consecutive patients referred to Bu Ali Sina Hospital from 2016 to 2023, who were hospitalized with a diagnosis of ischemic stroke. The records of all patients treated with intravenous alteplase during the above period were extracted, and the relevant characteristics were recorded in a questionnaire. In each year, patients with ischemic stroke who were not treated with alteplase but were hospitalized at the Bu Ali Center were selected in a similar number to patients who received alteplase in the same year, and the relevant information was extracted from their records and recorded in a questionnaire. The incidence of post-stroke seizures and epilepsy was determined in both groups, and the factors associated with their incidence were studied and compared.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients with ischemic stroke who received alteplase | Patients with ischemic stroke who received thrombolytic therapy with alteplase | ||
| Patients with ischemic stroke who did not receive alteplase | Patients with ischemic stroke who did not receive thrombolytic therapy |
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| Measure | Description | Time Frame |
|---|---|---|
| Incidence rate of post-stroke seizure | Incidence rate of post-stroke seizure in patients who received alteplase compared to patients who did not receive alteplase. | within 7 days following ischemic stroke onset |
| Incidence rate of post-stroke epilepsy | Incidence rate of post-stroke epilepsy in patients who received alteplase compared to patients who did not receive alteplase. | 1 to 7 years following ischemic stroke onset |
| Measure | Description | Time Frame |
|---|---|---|
| Factors related to post-stroke seizure occurrence | Demographic factors are registered in the questionnaire based on the patients' files. The severity of ischemic stroke is determined by the National Institutes of Health Stroke Scale (NIHSS). Brain CT findings including territory of infarct, cortical involvement and hemorrhagic transformation are investigated by reviewing the CT scans and recording the results in the questionnaire. Correlation of each mentioned factor with post-stroke seizure occurrence will be assessed using statistical methods. |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with ischemic stroke who were admitted between 2016 and 2023 in Bu Ali Sina hospital
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Mazandaran University of Medical Sciences | Sari | Mazandaran | Iran |
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| within 7 days following ischemic stroke onset |
| Factors related to post-stroke epilepsy occurrence | Demographic factors are registered in the questionnaire based on the patients' files. The severity of ischemic stroke is determined by the National Institutes of Health Stroke Scale (NIHSS). Brain CT findings including territory of infarct, cortical involvement and hemorrhagic transformation are investigated by reviewing the CT scans and recording the results in the questionnaire. Correlation of each mentioned factor with post-stroke epilepsy occurrence will be assessed using statistical methods. | 1 to 7 years following ischemic stroke onset |