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The goal of this clinical trial is to learn if oral melatonin can enhance visual acuity and central macular thickness in central serous chorioretinopathy (CSCR) in adults. The main questions it aims to answer are:
Participants will:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Case group: treatment with oral melatonin | Experimental | In the case group, the patients with central serous chorioretinopathy will receive oral melatonin within one month and outcomes will be assessed after finishing the course of the treatment, and 1 and 3 months later. |
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| Placebo group: treatment with placebo | Placebo Comparator | In the placebo group, the patients with central serous chorioretinopathy will receive the placebo substance after finishing the course of the treatment, and 1 and 3 months later. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| melatonin 3mg | Drug | In this group, participants will be randomly assigned to take 3 mg tablets of melatonin twice a day for 1 month. |
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| Measure | Description | Time Frame |
|---|---|---|
| central macular thickness (CMT) | Changes in central macular thickness (CMT) in patients receiving oral melatonin versus patients receiving placebo | From enrollment to 3 month later |
| best visual acuity (BCVA) | Changes in best visual acuity (BCVA) in patients receiving oral melatonin versus patients receiving placebo | From enrollment to 3 months later |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Mohsen Pourazizi | Contact | 98 + 09379578055 | m.pourazizi@yahoo.com |
| Name | Affiliation | Role |
|---|---|---|
| Mohsen Pourazizi | Isfahan University of Medical Sciences, Feiz Hospital, Isfahan Isfahan, Isfahan, Iran | Study Director |
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| ID | Term |
|---|---|
| D056833 | Central Serous Chorioretinopathy |
| ID | Term |
|---|---|
| D012164 | Retinal Diseases |
| D005128 | Eye Diseases |
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| ID | Term |
|---|---|
| D008550 | Melatonin |
| ID | Term |
|---|---|
| D014363 | Tryptamines |
| D007211 | Indoles |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
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| Placebo Drug | Drug | The placebo is also prepared in the form of tablets with similar packaging as melatonin by the pharmaceutical company. Participants will be randomly assigned to take placebo with the same frequency and duration as melatonin (twice a day for 1 month). |
|
| D006571 | Heterocyclic Compounds |
| D006728 | Hormones |
| D006730 | Hormones, Hormone Substitutes, and Hormone Antagonists |