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Melanoma is one of the most aggressive solid cancers, although mortality can be reduced with early treatment. Immunotherapy has transformed the prognosis of this pathology.
The sentinel lymph node technique is used to classify the severity of melanoma. It is proposed for melanomas with a Breslow thickness of 0.8 mm to 1 mm, and recommended for melanomas greater than 1 mm or with ulceration, whatever the Breslow index.
This technique is particularly useful for assessing pathology by detecting the presence of lymph node metastases. Patients with lymph node involvement (micro or macro) are eligible for adjuvant treatment.
The new recommendations suggest adjuvant immunotherapy for stages IIB and IIC (without lymph node involvement assessed by the sentinel lymph node technique). This procedure is widely used at the CHRU de NANCY.
The aim of this study is to demonstrate the value of the sentinel lymph node in assessing the risk of melanoma recurrence at one year (or more).
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| Measure | Description | Time Frame |
|---|---|---|
| Death or recurrence one year after diagnosis | Death or recurrence one year after diagnosis measured through the one-year reassessment (clinical or radiological evaluation). | 1 year |
| Measure | Description | Time Frame |
|---|---|---|
| Overall survival | To evaluate the overall survival one year after diagnosis in melanoma patients eligible for a sentinel lymph node biopsy. | 4 years |
| predictive factors of mortality or recurrence one year after diagnosis |
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Inclusion Criteria:
Major patient with a melanoma with a Breslow index greater than 0.8mm or ulcerated melanoma, non-metastatic at diagnosis,
Exclusion Criteria:
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Patients followed at the CHRU de Nancy or at the ICL between 01/01/2019 and 31/12/2023 and who does not object to the collection of his/her data.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHRU Nancy | Vandœuvre-lès-Nancy | Grand Est | 54500 | France |
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| ID | Term |
|---|---|
| D008545 | Melanoma |
| ID | Term |
|---|---|
| D018358 | Neuroendocrine Tumors |
| D017599 | Neuroectodermal Tumors |
| D009373 | Neoplasms, Germ Cell and Embryonal |
| D009370 | Neoplasms by Histologic Type |
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To evaluate the predictive factors of mortality or recurrence one year after diagnosis in melanoma patients eligible for a sentinel lymph node biopsy.
| 4 years |
| the recurrence-free survival | To evaluate the recurrence-free survival of melanoma patients eligible for a sentinel lymph node biopsy. | 4 years |
| complications associated with the sentinel lymph node biopsy | To evaluate the complications associated with the sentinel lymph node biopsy. | 4 years |
| recurrence-free survival of patients over 70 years old | To evaluate the recurrence-free survival of patients over 70 years old with melanoma eligible for a sentinel lymph node biopsy. | 4 years |
| post-sentinel lymph node biopsy treatments | To describe post-sentinel lymph node biopsy treatments | 4 years |
| the tolerance of adjuvant treatment. | To document the tolerance of adjuvant treatment. | 4 years |
| D009369 | Neoplasms |
| D009380 | Neoplasms, Nerve Tissue |
| D018326 | Nevi and Melanomas |
| D012878 | Skin Neoplasms |
| D009371 | Neoplasms by Site |
| D012871 | Skin Diseases |
| D017437 | Skin and Connective Tissue Diseases |