This study aims to investigate the effect of a structured exercise program on microRNA-126 (miR-126) expression in individuals with prediabetes.

This study aims to investigate the effect of a structured exercise program on microRNA-126 (miR-126) expression in individuals with prediabetes. The hypothesis of our study is that regular aerobic exercise will increase miR-126 expression. Determining the effect of exercise on miR-126 in individuals with prediabetes will contribute to the elucidation of the pathways through which exercise is effective in prediabetes via epigenetic mechanisms.

Inclusion Criteria:

• Individuals who were newly diagnosed with prediabetes according to the Oral Glucose Tolerance Test (OGTT) and/or HbA1C criteria
• between the ages of 18-60
• were physically inactive (Level 1 according to the International Physical Activity Questionnaire)
• were motivated to exercise
• Individuals who had no obstacle to exercise as a result of the evaluation made by a cardiologist (ECG, exercise ECG test, etc.)
• and who did not show a change in body weight of more than ±2.5 kg in the last six months were included in the study.

Exclusion Criteria:

• presence of serious medical conditions (e.g. advanced cancer, major neurological or endocrine disorders, respiratory failure)
• current cardiovascular disease, BMI <19 kg/m²
• history of metformin use within the last 6 months
• receiving hormone replacement therapy
• life expectancy less than one year
• HIV positivity
• substance use
• or orthopedic and cognitive disorders that may prevent exercise