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| ID | Type | Description | Link |
|---|---|---|---|
| 2016-A01861-50 | Registry Identifier | IDRCB |
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| Name | Class |
|---|---|
| Fondation des Gueules Cassées | UNKNOWN |
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Facial palsy (of one hemiface) affects the sensorimotor representation of the face of the patients, and possibly also their mental representation of emotional facial expressions. Three surgical techniques are performed to rehabilitate the face motricity in patients with severe facial palsy: Facio-facial anastomosis (AFF), Hypoglosso-facial anastomosis (AHF), and Lengthening temporalis myoplasty (LTM). Our objective is to study brain plasticity and facial emotion recognition in patients with facial palsy before and after surgical rehabilitation, using non invasive magnetoencephalography (MEG) recording during motor and emotion recognition tasks.
Facial palsy (of one hemiface) affects the sensorimotor representation of the face of the patients, and possibly also their mental representation of emotional facial expressions. Patients with severe facial palsy can benefit from surgical rehabilitation, allowing them to recover the motor and expressive function of the face. Three surgical techniques are performed to rehabilitate facial palsy: Facio-facial anastomosis (AFF), Hypoglosso-facial anastomosis (AHF), and Lengthening temporalis myoplasty (LTM). Prinicipal objective is to study brain plasticity and facial emotion recognition in patients with facial palsy before and after surgical rehabilitation. For this, the investigators will use magnetoencephalography (MEG), which is a non-invasive brain imaging method with high temporal and good spatial resolution.
Twenty patients with facial palsy will be included in the study. They will undergo two visits, during which MEG will be recorded in two types of tasks: motor task and emotion recognition task (see below). One visit will take place before surgery. The second visit will take place after the surgical intervention and the face motor rehabilitation, 3 to 18 months after the 1st visit.
MOTOR TASK: The motor task will comprise 5 types of simple movements: eye blinks, smiling, tongue protraction, teeth greeting, index flexion. These movements will be performed repetitively - at a pace of about 1 movement every 2 second - in separate, randomly alternating, blocks of 24 movements of each type, for a total of 120 movements of each type.
EMOTION RECOGNITION TASK: A total of 320 faces will be presented to the patients. The faces will be distributed in 5 blocks of 16 different faces (8 male, 8 female), displaying each of 4 emotional expressions: happiness, anger, sadness, and neutral expression. Occasional suprised target faces will be added. The patient's task will be to report the occurrence of those faces by pressing a button in his/her dominant hand. The stimuli will be presented in random order in each block.
The investogators will analyze neuromagnetic activities at the sensor and source levels during the motor tasks (primary objective) and in response to the faces (secondary objective).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Behavioral tasks with MEG recording | Other |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Behavioral tasks with MEG recording | Device | The patients will undergo two visits, during which MEG will be recorded in two types of behavioral tasks: motor task and emotion recognition task. One visit will take place before surgery. The second visit will take place after the surgical intervention and the face motor rehabilitation, 3 to 18 months after the 1st visit. |
| Measure | Description | Time Frame |
|---|---|---|
| Magnetoencephalography (MEG) activities during facial motor tasks | Magnetoencephalography (MEG) activities during the motor tasks | between 3 and 18 months |
| Measure | Description | Time Frame |
|---|---|---|
| Magnetoencephalography (MEG) activities in reponse to emotional faces | Magnetoencephalography (MEG) activities in reponse to sad, angry, happy, and neutral faces during the facial emotion recognition task | between 3 and 18 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Frédéric TANKERE, MD, PhD | Assistance Publique - Hôpitaux de Paris | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Frederic TANKERE | Paris | 75651 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 25252584 | Background | Foirest C, Gatignol P, Bernat I, Lamas G, Tankere F. [Lengthening temporalis myoplasty for facial palsy reanimation after parotid surgery]. Rev Laryngol Otol Rhinol (Bord). 2013;134(4-5):259-65. French. | |
| 23623628 | Background | Garmi R, Labbe D, Coskun O, Compere JF, Benateau H. Lengthening temporalis myoplasty and brain plasticity: a functional magnetic resonance imaging study. Ann Chir Plast Esthet. 2013 Aug;58(4):271-6. doi: 10.1016/j.anplas.2013.03.002. Epub 2013 Apr 23. |
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| 17973031 | Background | Leonetti JP, Anderson DE, Marzo SJ, Origitano TC, Petruzzelli GJ. Intratemporal Grafting of the Facial Nerve following Lateral Skull Base Tumor Resection. Skull Base. 2007 May;17(3):181-6. doi: 10.1055/s-2007-977464. |
| 22926020 | Background | Memarian N, Ferrari P, Macdonald MJ, Cheyne D, De Nil LF, Pang EW. Cortical activity during speech and non-speech oromotor tasks: a magnetoencephalography (MEG) study. Neurosci Lett. 2012 Oct 3;527(1):34-9. doi: 10.1016/j.neulet.2012.08.030. Epub 2012 Aug 25. |
| 25120453 | Background | Miki K, Kakigi R. Magnetoencephalographic study on facial movements. Front Hum Neurosci. 2014 Jul 29;8:550. doi: 10.3389/fnhum.2014.00550. eCollection 2014. |
| 15044504 | Background | Nakahara H, Nakasato N, Kanno A, Murayama S, Hatanaka K, Itoh H, Yoshimoto T. Somatosensory-evoked fields for gingiva, lip, and tongue. J Dent Res. 2004 Apr;83(4):307-11. doi: 10.1177/154405910408300407. |
| 9626677 | Background | Nakamura A, Yamada T, Goto A, Kato T, Ito K, Abe Y, Kachi T, Kakigi R. Somatosensory homunculus as drawn by MEG. Neuroimage. 1998 May;7(4 Pt 1):377-86. doi: 10.1006/nimg.1998.0332. |
| 11554811 | Background | Nakasato N, Itoh H, Hatanaka K, Nakahara H, Kanno A, Yoshimoto T. Movement-related magnetic fields to tongue protrusion. Neuroimage. 2001 Oct;14(4):924-35. doi: 10.1006/nimg.2001.0881. |
| 9153524 | Background | Rijntjes M, Tegenthoff M, Liepert J, Leonhardt G, Kotterba S, Muller S, Kiebel S, Malin JP, Diener HC, Weiller C. Cortical reorganization in patients with facial palsy. Ann Neurol. 1997 May;41(5):621-30. doi: 10.1002/ana.410410511. |
| 11954058 | Background | Salmelin R, Sams M. Motor cortex involvement during verbal versus non-verbal lip and tongue movements. Hum Brain Mapp. 2002 Jun;16(2):81-91. doi: 10.1002/hbm.10031. |
| 24363977 | Background | Suzuki M, Wasaka T, Inui K, Kakigi R. Reappraisal of field dynamics of motor cortex during self-paced finger movements. Brain Behav. 2013 Nov;3(6):747-62. doi: 10.1002/brb3.186. Epub 2013 Oct 17. |
| 15244163 | Background | Tankere F, Bernat I, Vitte E, Lamas G, Soudant J, Maisonobe T, Bouche P, Fournier E, Willer JC. [The hypolossal-facial anastomosis in man. A model for studying peripheral and central nervous system plasticity]. Rev Med Liege. 2004;59 Suppl 1:91-103. French. |
| 26654207 | Background | Vvedensky VL, Prokofyev AO. Timing of Cortical Events Preceding Voluntary Movement. Neural Comput. 2016 Feb;28(2):286-304. doi: 10.1162/NECO_a_00802. Epub 2015 Dec 14. |
| 11836756 | Background | Willer JC, Tankere F, Maisonobe T, Bernat I, Lamas G, Soudant J, Vitte E, Bouche P, Fournier E. Hypoglossal-facial anastomosis induced central plastic changes in the blink reflex circuitry. Mov Disord. 2002;17 Suppl 2:S53-7. doi: 10.1002/mds.10060. No abstract available. |
| 8464929 | Background | Yang TT, Gallen CC, Schwartz BJ, Bloom FE. Noninvasive somatosensory homunculus mapping in humans by using a large-array biomagnetometer. Proc Natl Acad Sci U S A. 1993 Apr 1;90(7):3098-102. doi: 10.1073/pnas.90.7.3098. |
| 38738297 | Result | Hervochon R, Chaumon M, Ziri D, Foirest C, Schwartz D, George N, Tankere F. Cerebral Plasticity after Lengthening Temporalis Myoplasty in Facial Palsy: A Magnetoencephalography Study. Facial Plast Surg Aesthet Med. 2025 Mar-Apr;27(2):145-147. doi: 10.1089/fpsam.2023.0235. Epub 2024 May 13. No abstract available. |
| ID | Term |
|---|---|
| D005158 | Facial Paralysis |
| ID | Term |
|---|---|
| D009059 | Mouth Diseases |
| D009057 | Stomatognathic Diseases |
| D010243 | Paralysis |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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