In sequential management, exercises are performed sequentially: 20 minutes of physical exercises and 20 minutes of cognitive exercises.

The 6MWT consists in measuring the distance (in meters) covered in 6 minutes by the participant. It is therefore a recommended tool for measuring walking endurance in MH patients. A straight, flat corridor measuring between 20 and 50 metres is marked out with coloured markers and two cones at either end. The patient is asked to walk as far as possible for 6 minutes, back and forth along the corridor. During the test, the patient can slow down and even stop if necessary, but is obliged to go around the cones at each half-turn. At the end of the 6 minutes, the patient must stop and not move until the distance covered is measured. The longer the total distance covered, the greater the walking endurance.

The 30CST consists of standing up and sitting down from a chair as many times as possible for thirty seconds, without physical assistance. The greater the number of repetitions, the greater the muscular strength of the lower limbs.

The MMSE enables us to assess global cognitive functioning on a 30-point scale. It comprises 6 subsections: orientation, learning, attention and calculation, recall, language and constructive praxis, scored out of 10, 3, 5, 3, 8 and 1 respectively. The test takes 10 minutes to complete. The higher the score, the better the performance. A score between 22 and 25 suggests mild dementia, between 16 and 20 moderate dementia, between 10 and 15 moderately severe dementia, between 3 and 9 severe dementia and finally very severe dementia below 3. It will be used in this study to check inclusion criteria and assess the patient's overall cognitive abilities.

The WAIS IV "Digit Memory" sub-test is frequently used in neuropsychological practice to assess auditory attention and auditory working memory. The assessment is carried out in three stages. First, the patient is asked to repeat the digits dictated orally by the evaluator. The exercise starts with 2 digits, and increases after at least one successful attempt out of two. The principle is the same for the next exercise, during which the subject must repeat the sequence of digits in the reverse order to that dictated. For the last exercise, the subject must reconstruct the sequence of numbers in ascending order. Each attempt is marked 0 or 1. The total score is then calculated.

The Stroop test assesses inhibition. Three boards are presented: the first consists of naming colored rectangles (blue, green or red) and the second of naming words written in letters (blue, green or red). On the third board, the words designating the colors are printed in ink of a different color from that designated. The subject must inhibit reading the word in order to name the ink color.

During the SDMT, which assesses patients' psychomotor speed and working memory, the numbers from 1 to 9 are each associated with a specific symbol on a model. The participant must assign the numbers to the symbols presented line by line. The aim is to correctly associate as many numbers as possible with the different symbols within 90 seconds. The support is written and the model remains in front of the patient for the duration of the test.

The verbal fluency task assessing mental flexibility is composed of two tests: semantic fluency and phonological fluency. In the semantic fluency test, the patient is asked to generate as many words as possible in 1 minute from a category (e.g. fruit, animals, etc.). In the phonological fluency test, the patient is asked to generate a maximum number of words in 1 minute from a letter (e.g. P, R or V).

The Trail Making Test is a paper-and-pencil test that assesses spontaneous flexibility. It is offered in two parts. In part A, the subject is asked to connect numbers from 1 to 25 as quickly as possible. For part B, the subject is asked to connect numbers and letters, alternating the number/letter sequence and maintaining ascending numbering and alphabetical order. All stimuli are presented and two examples are performed before each part. Time and errors are recorded.

The Hospital Anxiety and Depression Scale (HADS) is a self-administered questionnaire frequently used to detect anxiety and depressive disorders, common in patients with HD. The self-assessment scale lasts 10 minutes and comprises 14 items (7 for depression and 7 for anxiety) rated from 1 to 3. At the end we then obtain two scores:

• An anxiety score between 7 and 21. The higher the score, the more severe and disabling the symptoms.
• A depression score between 7 and 21. The higher the score, the greater and more disabling the symptoms.

The Problem Behaviours Assessment for Huntington's Disease (PBA-HD) is a semi-structured interview questionnaire used to highlight the various behavioural and psychiatric problems that can arise with HD. The original version covers 40 items, but the short version (PBA-s) covers 11 items and evaluates them over the last 4 weeks. Thus, the short version is more commonly used in clinical studies. The 11 items assessed are : Depression; Suicidal ideation; Anxiety; Irritability; Aggressive behavior; Apathy; Perseverative thinking; Obsessive-compulsive disorder; Paranoia; Hallucinations; Disorientation.

Each item is evaluated with specific questions to produce two types of score:

• A severity score between 0 and 4. The higher the score, the more severe the symptoms.
• A frequency score between 0 and 4. The higher the score, the more frequent the symptoms.

The quality of life of patients with HD will be assessed using the SF-12, which is a short version of the SF-36. This is the generic questionnaire most widely used internationally to assess quality of life. It is a 36-question self-administered questionnaire covering eight health domains: the SF-12 consists of 12 questions divided into the same 8 domains as the SF36.

• Physical functioning
• Social functioning
• Limitations due to physical problems
• Limitations due to emotional problems
• Mental health
• Vitality
• Pain
• General perception of health For each domain, the scores of the various questions are coded, added together and transformed into a scale ranging from 0 (very poor health) to 100 (very good health).

Acceptance and feasibility of the two rehabilitation programs are assessed by the number of sessions completed, the drop-out rate, the rate of correct answers, the rate of early interruption of the session and the duration of the session, as well as by questions on subjective appreciation of the program. Subjective appraisal questions ask patients about the attractiveness of the program (motivation); the clarity, effectiveness and reliability of the exercises (safety); and the hedonic quality (creativity, stimulation) of the program. Patients were asked to answer these questions on a scale from 0 (strongly disagree) to 5 (strongly agree).

• Do you think the rehabilitation program is attractive (environment, aesthetics)?
• Do you think the program is effective for your disease?
• Do you find the information conveyed sufficiently clear (instructions, exercise answers)?
• Do you feel safe doing the exercises?
• Are the exercises motivating and stimulating?

Participants' satisfaction with the program is assessed using a numerical scale: "How would you rate the program and its support overall?" on a scale from 0 (not at all satisfactory) to 5 (completely satisfactory). An open-ended question allows participants to add comments to justify the rating they have received, or to describe how they feel about the program ("Can you justify your rating in a few words, and describe how you feel about the program").