Liquid biopsy is a noninvasive method for detecting and quantifying circulating tumor cells (CTCs). Thanks to ScreenCell technology, this study aims to evaluate the evolution of the number of CTCs during breast cancer follow-up.

The identification and characterization of CTCs would make it possible to obtain information on the stage and molecular characteristics of cancer during follow-up

INCLUSION CRITERIA

For all participants :

• Female with age greater than or equal to 18 years

For participants with metastatic breast cancer:

- Patient observed with metastatic breast cancer from the outset or metastatic fall from previously treated breast cancer with change of therapeutic line at the time of inclusion.

For participants with non-metastatic invasive breast cancer:

- Patient observed with non-metastatic infiltrative breast cancer who had not received any treatment at the time of inclusion (naïve to any treatment)

For healthy volunteers:

• Participant free of any cancer at the time of inclusion, confirmed using a mammogram whose results must be satisfactory, done at the latest two years before inclusion
• Participant with no history of cancer

EXCLUSION CRITERIA

For all participants:

• Male
• Age less than 18 years old
• Refusal to participate or withdrawal of consent
• Pregnant and/or breastfeeding women
• Discovery of a cancerous pathology (other than breast cancer for patients) during participant follow-up.

For healthy volunteers:

• History of cancer
• Detection of CTC (positive profile) during screening

Only individuals who self-identify as female are eligible to participate to evaluate breast cancer within a homogenized cohort, ensuring more relevant and reliable biostatistical analyses