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| ID | Type | Description | Link |
|---|---|---|---|
| 2024-517284-23-00 | Registry Identifier | EUCT number |
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The purpose of this study is to evaluate the efficacy of icotrokinra (JNJ-77242113) compared to placebo in biologic-experienced and biologic-naive participants with active psoriatic arthritis (PsA) by assessing the reduction in signs and symptoms of PsA.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group I: Icotrokinra Dose 1 | Experimental | Participants will receive icotrokinra Dose 1. Participants who have not discontinued will be eligible to enter a long term extension (LTE) and will continue to receive icotrokinra Dose 1. |
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| Group II: Icotrokinra Dose 2 | Experimental | Participants will receive icotrokinra Dose 2. Participants who have not discontinued will be eligible to enter a LTE and will continue to receive icotrokinra Dose 2. |
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| Group III: Placebo | Placebo Comparator | Participants will receive placebo matched to icotrokinra and will cross over to receive icotrokinra Dose 1 or Dose 2 at Week 16. Participants who have not discontinued will be eligible to enter a LTE and will continue to receive icotrokinra Dose 1 or Dose 2. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Icotrokinra | Drug | Icotrokinra will be administered. |
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| Measure | Description | Time Frame |
|---|---|---|
| Proportion of Participants who Achieved an American College of Rheumatology (ACR) 20 Response at Week 16 | The ACR 20 responders are participants with an improvement of greater than or equal to (>=) 20 percent (%) from baseline in both the tender and swollen joint count and in at least 3 of the 5 assessments (patient's assessment of pain visual analog scale (VAS), patient's global assessment of disease activity [arthritis, VAS] scale, Physician's global assessment of disease activity VAS scale, Health Assessment Questionnaire and C-reactive protein). | Week 16 |
| Measure | Description | Time Frame |
|---|---|---|
| Proportion of Participants Who Achieved Psoriatic Area and Severity Index (PASI) 75 Response at Week 16 Among Participants with Baseline Body Surface Area (BSA) Greater Than Equal to (>=) 3 Percent (%) and With Baseline IGA Score of >=2 | The PASI is a system used for assessing and grading the severity of psoriatic lesions. In the PASI system, the body is divided into 4 regions: the head, trunk, upper extremities, and lower extremities. Each of these areas were assessed separately for the percentage of the area involved, which translates to a numeric score that ranges from 0 to 6, and for erythema, induration, and scaling, which are each rated on a scale of 0 to 4. The PASI produces a numeric score that can range from 0 to 72. A higher score indicates more severe disease. A PASI 75 response represents participants who achieved at least a 75 percent improvement from baseline in the PASI score. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Study Contact | Contact | 844-434-4210 | Participate-In-This-Study1@its.jnj.com |
| Name | Affiliation | Role |
|---|---|---|
| Janssen Research & Development, LLC Clinical Trial | Janssen Research & Development, LLC | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| AARA Clinical Research | Recruiting | Glendale | Arizona | 85306 | United States | |
| AARA Clinical Research 1 |
The data sharing policy of Johnson & Johnson Innovative Medicine is available at innovativemedicine.jnj.com/our-innovation/clinical-trials/transparency. As noted on this site, requests for access to the study data can be submitted through Yale Open Data Access (YODA) Project site at yoda.yale.edu
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| Placebo | Drug | Placebo will be administered. |
|
| Week 16 |
| Proportion of Participants Who Achieved PASI 90 Response at Week 16 Among Participants with Baseline BSA >=3% and With Baseline IGA Score of >=2 | The PASI is a system used for assessing and grading the severity of psoriatic lesions. In the PASI system, the body is divided into 4 regions: the head, trunk, upper extremities, and lower extremities. Each of these areas were assessed separately for the percentage of the area involved, which translates to a numeric score that ranges from 0 to 6, and for erythema, induration, and scaling, which are each rated on a scale of 0 to 4. The PASI produces a numeric score that can range from 0 to 72. A higher score indicates more severe disease. A PASI 90 response represents participants who achieved at least a 90 percent improvement from baseline in the PASI score. | Week 16 |
| Proportion of Participants Who Achieved PASI 100 Response at Week 16 Among Participants with Baseline BSA >=3% and With Baseline IGA Score of >=2 | The PASI is a system used for assessing and grading the severity of psoriatic lesions. In the PASI system, the body is divided into 4 regions: the head, trunk, upper extremities, and lower extremities. Each of these areas were assessed separately for the percentage of the area involved, which translates to a numeric score that ranges from 0 to 6, and for erythema, induration, and scaling, which are each rated on a scale of 0 to 4. The PASI produces a numeric score that can range from 0 to 72. A higher score indicates more severe disease. A PASI 100 response represents participants who achieved at least a 100 percent improvement from baseline in the PASI score. | Week 16 |
| Proportion of Participants with an Investigator Global Assessment (IGA) Psoriasis Score of 0 or 1 And >=2 Grade Improvement From Baseline at Week 16 Among Participants with Baseline BSA >=3% and With Baseline IGA Score of >=2 | Proportion of participants with an IGA psoriasis score of 0 or 1 And >=2 grade improvement from baseline at Week 16 among participants with >=3% BSA and an IGA Score of >=2 at Baseline will be reported. The IGA documents the investigator's assessment of the participant's psoriasis at a given time point. Overall lesions are graded for induration, erythema, and scaling, each using a 5-point scale: using 0 (no evidence), 1 (minimal), 2 (mild), 3 (moderate), and 4 (severe) scale. The IGA score of psoriasis is based upon the average of induration, erythema, and scaling scores. The participant's psoriasis is assessed as cleared (0), minimal (1), mild (2), moderate (3), or severe (4). | Week 16 |
| Proportion of Participants who Achieved an ACR 50 Response at Week 16 | The ACR 50 responders are participants with an improvement of >= 50% from baseline in both the tender and swollen joint count and in at least 3 of the 5 assessments (patient's assessment of pain VAS, patient's global assessment of disease activity (arthritis, VAS) scale, Physician's global assessment of disease activity VAS scale, Health Assessment Questionnaire and C-reactive protein). | Week 16 |
| Proportion of Participants who Achieved an ACR 70 Response at Week 16 | The ACR 70 responders are participants with an improvement of >= 70% from baseline in both the tender and swollen joint count and in at least 3 of the 5 assessments (patient's assessment of pain VAS, patient's global assessment of disease activity (arthritis, VAS) scale, Physician's global assessment of disease activity VAS scale, health assessment questionnaire and C-reactive protein). | Week 16 |
| Change From Baseline in Health Assessment Questionnaire-Disability Index (HAQ-DI) Score At Week 16 | The HAQ-DI score consists of questions referring to 8 categories: dressing/grooming, arising, eating, walking, hygiene, reach, grip, and common daily activities. Responses in each functional area are scored from 0 to 3 (0=no difficulty and 3=inability to perform a task in that area). Overall score was computed as the sum of domain scores and divided by the number of domains answered. Total possible score range 0-3 where 0 = least difficulty and 3 = extreme difficulty. | From baseline up to Week 16 |
| Changes From Baseline in 36 Item Short Form Survey (SF-36) Physical Component Summary (PCS) Score at Week 16 | SF-36 is a standardized survey evaluating 8 aspects of functional health and wellbeing: physical and social functioning, physical and emotional role limitations, bodily pain, general health, vitality, mental health. The score for a domain was an average of the individual question scores, which were scaled 0 to 100 (100=highest level of functioning). Score from physical function, role physical, bodily pain, and general health domains were averaged to calculate PCS. Total score range for PCS was 0-100 (100=highest level of physical functioning). | From baseline up to Week 16 |
| Proportion of Participants With Resolution of Enthesitis at Week 16 Among Those With Enthesitis at Baseline | Enthesitis will be assessed using the Leeds Enthesitis Index (LEI). The LEI was developed to assess enthesitis in participants with PsA, and evaluates the presence (score of 1) or absence of pain (score of 0) by applying local pressure to Lateral elbow epicondyle, left and right, Medial femoral condyle, left and right, and Achilles tendon insertion, left and right. LEI scores ranging from 0 (0 sites with tenderness) to 6 (worst possible score; 6 sites with tenderness). | Week 16 |
| Change From Baseline in Enthesitis Score at Week 16 in Participants With Enthesitis at Baseline | Enthesitis will be assessed using the LEI. The LEI was developed to assess enthesitis in participants with PsA, and evaluates the presence (score of 1) or absence of pain (score of 0) by applying local pressure to Lateral elbow epicondyle, left and right, Medial femoral condyle, left and right, and Achilles tendon insertion, left and right. LEI scores ranging from 0 (0 sites with tenderness) to 6 (worst possible score; 6 sites with tenderness). | Baseline and Week 16 |
| Proportion of Participants With Resolution of Dactylitis at Week 16 Among Those With Dactylitis at Baseline | Dactylitis is characterized by swelling of the entire finger or toe. Presence and severity of dactylitis will be assessed in both hand and feet using a scoring system from 0 to 3 (0: no dactylitis, 1: mild dactylitis, 2: moderate dactylitis, 3: severe dactylitis). The result for each digit are summed to produce a final dactylitis score with a range from 0 to 60. Higher score indicates greater severity. | Week 16 |
| Change From Baseline in Dactylitis Score at Week 16 in Participants With Dactylitis at Baseline | Dactylitis is characterized by swelling of the entire finger or toe. Presence and severity of dactylitis will be assessed in both hand and feet using a scoring system from 0 to 3 (0: no dactylitis, 1: mild dactylitis, 2: moderate dactylitis, 3: severe dactylitis). The result for each digit are summed to produce a final dactylitis score with a range from 0 to 60. Change from baseline in dactylitis score measure the change in dactylitis, where a negative change indicates an improvement and a positive change indicates a worsening. | From baseline up to Week 16 |
| Proportion of Participants who Achieved Minimal Disease Activity (MDA) at Week 16 | MDA criteria are a composite of 7 outcome measures used in PsA. Participants are classified as achieving MDA if they fulfill at least 5 out of the 7 outcome measures: tender joint count less than or equal to (<=) 1; swollen joint count <= 1; psoriasis activity and severity index <= 1 or body surface area <= 3 percent (%); patient pain VAS score of <= 15; patient global disease activity VAS (arthritis and psoriasis) score of <= 20; health assessment questionnaire (HAQ) score <= 0.5; and tender entheseal points <= 1. | Week 16 |
| Change From Baseline in Functional Assessment of Chronic Illness Therapy (FACIT)-Fatigue Score at Week 16 | The FACIT-fatigue is a self-administered, 13 item questionnaire measuring items on tiredness, weakness, and difficulty conducting usual activities due to fatigue. Responses to all items are rated on a 5-point Likert response scale ranging from 0 "not at all" to 4 "very much." The total score ranges from 0 to 52, with higher values indicating less fatigue. | From baseline up to Week 16 |
| Recruiting |
| Mesa |
| Arizona |
| 85210 |
| United States |
| Arthritis and Rheumatism Associates ARA Jonesboro | Recruiting | Jonesboro | Arkansas | 72401 | United States |
| Clinical Research of West Florida | Recruiting | Clearwater | Florida | 33765 | United States |
| Omega Research Consultants | Recruiting | DeBary | Florida | 32713 | United States |
| Suncoast Clinical Research | Recruiting | New Port Richey | Florida | 34652 | United States |
| Integral Rheumatology And Immunology Specialists | Recruiting | Plantation | Florida | 33324 | United States |
| Clinical Research of West Florida 1 | Recruiting | Tampa | Florida | 33606 | United States |
| Clinic of Robert Hozman | Completed | Skokie | Illinois | 60076 | United States |
| Klein And Associates M D P A | Recruiting | Hagerstown | Maryland | 21740 | United States |
| DM Clinical Research 1 | Completed | Brookline | Massachusetts | 02446 | United States |
| St Paul Rheumatology PA | Recruiting | Eagan | Minnesota | 55123 | United States |
| Albuquerque Rehabilitation and Rheumatology | Recruiting | Albuquerque | New Mexico | 87102 | United States |
| Joint and Muscle Research Institute | Recruiting | Charlotte | North Carolina | 28204 | United States |
| Rheumatology Associates of Oklahoma | Recruiting | Oklahoma City | Oklahoma | 73116 | United States |
| Altoona Center For Clinical Research | Recruiting | Duncansville | Pennsylvania | 16635 | United States |
| Arthritis and Rheumatology Research Institute | Recruiting | Allen | Texas | 75013 | United States |
| UT Southwestern | Recruiting | Dallas | Texas | 75390 | United States |
| Naiara Alvarez MD Integrative Rheumatology of South TX | Suspended | Harlingen | Texas | 78550 | United States |
| AARA Clinical Research Lone Star Arthritis and Rheumatology | Recruiting | Irving | Texas | 75039 | United States |
| DM Clinical Research | Recruiting | Tomball | Texas | 77375 | United States |
| Velocity Clinical Research | Recruiting | Waco | Texas | 76710 | United States |
| Seattle Rheumatology | Recruiting | Seattle | Washington | 98104 | United States |
| Center of Rheumatic Diseases | Recruiting | Glendale | Wisconsin | 53217 | United States |
| Instituto Medico De Alta Complejidad (IMAC) | Recruiting | Buenos Aires | B1643CRO | Argentina |
| ARCIS Salud SRL Aprillus asistencia e investigacion | Recruiting | Buenos Aires | C1406AGA | Argentina |
| Hospital Militar Central Cir. My. Dr. Cosme Argerich | Recruiting | Buenos Aires | C1426 | Argentina |
| Arsema | Recruiting | Ciudad de Buenos Aires | C1431 | Argentina |
| Centro Medico Privado de Reumatologia Tucuman | Recruiting | Ciudad de San Miguel de Tucuman | T4000AXL | Argentina |
| MR Medicina Reumatologica | Recruiting | San Fernando | B1646GHP | Argentina |
| Ipswich Hospital | Recruiting | Ipswich | 4305 | Australia |
| Rheumatology Research Unit | Recruiting | Maroochydore | 4558 | Australia |
| Queen Elizabeth Hospital | Recruiting | South Woodville | 5011 | Australia |
| Royal North Shore Hospital | Recruiting | St Leonards | 2065 | Australia |
| Royal Darwin Hospital | Recruiting | Tiwi | 0810 | Australia |
| Universidade Federal de Minas Gerais UFMG Faculdade de Medicina | Recruiting | Belo Horizonte | 30130 100 | Brazil |
| LMK Servicos Medicos S S | Recruiting | Porto Alegre | 90480 000 | Brazil |
| Fundacao Faculdade Regional De Medicina S Jose Rio Preto Hospital De Base | Recruiting | São José do Rio Preto | 15090-000 | Brazil |
| BR TRIALS Ensaios Clinicos e Consultoria Ltda | Recruiting | São Paulo | 01236030 | Brazil |
| CEPIC Centro Paulista de Investigacao Clinica e Servicos Medicos | Recruiting | São Paulo | 04266 010 | Brazil |
| Hospital Das Clinicas Da Faculdade De Medicina Da USP | Recruiting | São Paulo | 05403 900 | Brazil |
| UMHAT Kaspela | Recruiting | Plovdiv | 4001 | Bulgaria |
| Multiprofile Hospital for Active Treatment Plovdiv | Completed | Plovdiv | 4003 | Bulgaria |
| Diagnostic Consulting Center I Sliven | Recruiting | Sliven | 8801 | Bulgaria |
| Multiprofile Hospital for Active Treatment - MHAT Lyulin EAD | Recruiting | Sofia | 1336 | Bulgaria |
| MC Ekselsior | Completed | Sofia | 1407 | Bulgaria |
| Diagnostic-Consultative Center (DCC) Aleksandrovska | Recruiting | Sofia | 1431 | Bulgaria |
| UMHAT St. Ivan Rilski | Recruiting | Sofia | 1612 | Bulgaria |
| ASIMP Rheumatology Centre St Irina EOOD | Recruiting | Sofia | 1750 | Bulgaria |
| Eastern Regional Health Authority St Clares Mercy Hospital | Recruiting | St. John's | Newfoundland and Labrador | A1C 5B8 | Canada |
| The Waterside Clinic | Recruiting | Orillia | Ontario | L3V 1T5 | Canada |
| Womens College Hospital | Recruiting | Toronto | Ontario | M5S 1B1 | Canada |
| Alliance Clinical Trials | Completed | Waterloo | Ontario | N2J 1C4 | Canada |
| Dr Sabeen Anwar Medicine Professional Corporation | Recruiting | Windsor | Ontario | N8X 1T3 | Canada |
| Hospital Maisonneuve-Rosemont | Recruiting | Montreal | Quebec | H1T 2M4 | Canada |
| Centre de Recherche Musculo Squelettique | Recruiting | Trois-Rivières | Quebec | G9A 3X2 | Canada |
| Peking University Third Hospital | Recruiting | Beijing | 100191 | China |
| Beijing Tong Ren Hospital Capital Medical University | Recruiting | Beijing | 100730 | China |
| The First Bethune Hospital of Jilin University | Recruiting | Changchun | 130021 | China |
| Xiangya Hospital Central South University | Recruiting | Changsha | 410008 | China |
| West China Hospital Sichuan University | Recruiting | Chengdu | 610041 | China |
| Sichuan Provincial Peoples Hospital | Recruiting | Chengdu | 610072 | China |
| The First Affiliated Hospital of Chongqing Medical University | Recruiting | Chongqing | 400016 | China |
| Dongguan People s Hospital | Recruiting | Dongguan | 523109 | China |
| Nanfang Hospital of Southern Medical Hospital | Active, not recruiting | Guangzhou | 510515 | China |
| The Affiliated Hospital of Guizhou Medical University | Recruiting | Guiyang | 550004 | China |
| Sir Run Run Shaw Hospital Zhejiang University School of Medicine | Recruiting | Hangzhou | 310018 | China |
| The First Hospital of Jiaxing | Recruiting | Jiaxing | 314001 | China |
| Jinhua municipal central hospital | Recruiting | Jinhua | 321013 | China |
| Linfen Central Hospital | Recruiting | Linfen | 041000 | China |
| Linyi City People Hospital | Recruiting | Linyi | 276002 | China |
| The Second Affiliated Hospital of Nanchang University | Recruiting | Nanchang | 330008 | China |
| Affiliated Hospital of Nantong University | Recruiting | Nantong | 226001 | China |
| Pingxiang People's Hospital | Recruiting | Pingxiang | 337055 | China |
| Huashan Hospital Fudan University | Recruiting | Shanghai | 200040 | China |
| Shanghai skin disease hospital | Recruiting | Shanghai | 200443 | China |
| Shenzhen People s Hospital | Recruiting | Shenzhen | 518020 | China |
| Second Affiliated Hospital of Soochow University | Recruiting | Suzhou | 215004 | China |
| Shanxi Bethune Hospital | Recruiting | Taiyuan | 030032 | China |
| The First Affiliated Hospital of Wenzhou Medical University | Recruiting | Wenzhou | 325000 | China |
| The Second Affiliated Hospital of Xi'an Jiaotong University | Recruiting | Xi'an | 710006 | China |
| Revmacentrum MUDr Mostera s r o | Recruiting | Brno | 615 00 | Czechia |
| Revmatologie s r o | Recruiting | Brno | 63800 | Czechia |
| RHEUMA s r o | Recruiting | Břeclav | 690 02 | Czechia |
| L K N Arthrocentrum | Recruiting | Hlučín | 748 01 | Czechia |
| CCR Ostrava S R O | Recruiting | Ostrava | 70200 | Czechia |
| MUDr Rosypalova s r o | Recruiting | Ostrava | 708 00 | Czechia |
| FN Motol | Recruiting | Prague | 15000 | Czechia |
| Medical Plus S R O | Recruiting | Uherské Hradiště | 68601 | Czechia |
| PV Medical S R O | Recruiting | Zlín | 76001 | Czechia |
| Aarhus University Hospital | Recruiting | Aarhus N | 8200 | Denmark |
| Sydvestjysk Sygehus | Recruiting | Esbjerg | 6700 | Denmark |
| Frederiksberg Hospital | Recruiting | Frederiksberg | 2000 | Denmark |
| Regionshospitalet Godstrup | Recruiting | Herning | 7400 | Denmark |
| Svendborg Hospital Odense University Hospital | Recruiting | Svendborg | 5700 | Denmark |
| Vejle Sygehus | Recruiting | Vejle | 7100 | Denmark |
| Charite - Campus Mitte | Recruiting | Berlin | 10117 | Germany |
| ISA - Interdisciplinary Study Association GmbH | Recruiting | Berlin | 10789 | Germany |
| Medizinische Fakultaet Carl Gustav Carus Technische Universitaet Dresden | Completed | Dresden | 01307 | Germany |
| Medizinische Fakultaet Der Albert Ludwigs Universitaet Freiburg | Recruiting | Freiburg im Breisgau | 79106 | Germany |
| Hamburger Rheuma Forschungszentrum II | Recruiting | Hamburg | 20095 | Germany |
| Rheumazentrum Ruhrgebiet | Recruiting | Herne | 44649 | Germany |
| Praxis Dr. med. Beate Schwarz - Germany | Recruiting | Langenau | 89129 | Germany |
| Rheumaforschung - Studienambulanz Dr. Wassenberg | Completed | Ratingen | 40878 | Germany |
| Universitatsklinikum Tubingen | Recruiting | Tübingen | 72076 | Germany |
| Prince of Wales Hospital | Recruiting | Hong Kong | 000000 | Hong Kong |
| Queen Mary Hospital | Recruiting | Hong Kong | Hong Kong |
| Betegapolo Irgalmas Rend Budai Irgalmasrendi Korhaz | Recruiting | Budapest | 1023 | Hungary |
| Revita Kft | Recruiting | Budapest | 1027 | Hungary |
| Qualiclinic Kft | Recruiting | Budapest | 1134 | Hungary |
| Uno Medical Trials Ltd. | Recruiting | Budapest | 1152 | Hungary |
| Debreceni Egyetem Reumatologiai Klinika | Recruiting | Debrecen | 4032 | Hungary |
| Bekes Varmegyei Kozponti Korhaz Pandy Kalman Tagkorhaz | Recruiting | Gyula | 5700 | Hungary |
| Obudai Egeszsegugyi Centrum Kft | Completed | Kaposvár | 7400 | Hungary |
| Bacs Kiskun Varmegyei Oktatokorhaz | Recruiting | Kecskemét | 6000 | Hungary |
| University of Szeged | Recruiting | Szeged | 6725 | Hungary |
| Fejer Varmegyei Szent Gyorgy Egyetemi Oktatokorhaz | Recruiting | Székesfehérvár | 8000 | Hungary |
| MAV Korhaz es Rendelointezet | Recruiting | Szolnok | 5000 | Hungary |
| Vital Medical Center Orvosi es Fogaszati Kozpont | Recruiting | Veszprém | 8200 | Hungary |
| Marengo Cims Hospital | Recruiting | Ahmedabad | 380060 | India |
| Apollo Hospitals | Recruiting | Bhubaneswar | 751005 | India |
| Sushruta Multispeciality Hospital | Recruiting | Hubballi | 580021 | India |
| Apollo Multispeciality Hospital Ltd | Recruiting | Kolkata | 700054 | India |
| JSS Hospital | Completed | Mysuru | 570004 | India |
| All India Institute of Medical Sciences | Recruiting | New Delhi | 110029 | India |
| Indraprastha Apollo Hospital | Recruiting | New Delhi | 1100776 | India |
| Fortis Hospital | Recruiting | Noida | 201301 | India |
| SIDS (Surat Institute of Digestive Sciences) Hospital and Research Centre | Recruiting | Surat | 395002 | India |
| A.O. Universitaria Ospedali Riuniti di Ancona | Recruiting | Ancona | 60126 | Italy |
| ASST Spedali Civili Brescia | Recruiting | Brescia | 25123 | Italy |
| Policlinico San Marco | Recruiting | Catania | 95124 | Italy |
| Ospedale San Raffaele | Recruiting | Milan | 20132 | Italy |
| Azienda Ospedaliero Universitaria Luigi Vanvitelli | Recruiting | Naples | 80138 | Italy |
| IRCCS Policlinico San Matteo | Recruiting | Pavia | 27100 | Italy |
| Universita Degli Studi di Roma Tor Vergata | Recruiting | Roma | 00133 | Italy |
| Fondazione Policlinico Universitario A Gemelli IRCCS | Recruiting | Roma | 00168 | Italy |
| Istituto Clinico Humanitas | Recruiting | Rozzano | 20089 | Italy |
| A O Universitaria Senese Ospedale Santa Maria alle Scotte | Recruiting | Siena | 53100 | Italy |
| Ospedale S. Maria Della Misericordia | Recruiting | Udine | 33100 | Italy |
| NHO Chiba Medical Center Chibahigashi National Hospital | Recruiting | Chiba | 260-8712 | Japan |
| St. Luke's International Hospital | Recruiting | Chūōku | 104 8560 | Japan |
| Kansai Medical University Hospital | Recruiting | Hirakata | 573 1191 | Japan |
| Kita-harima Medical Center | Completed | Hyōgo | 6751392 | Japan |
| Hospital of the University of Occupational and Environmental Health | Recruiting | Kitakyushu-shi | 807-8556 | Japan |
| Nagoya City University Hospital | Recruiting | Nagoya | 467 8602 | Japan |
| Osaka Metropolitan University Hospital | Recruiting | Osaka | 545 8586 | Japan |
| Public Interest Incorporated Foundation Nipoon Life Saiseikai Nippon Life Hospital | Recruiting | Osaka | 550 0006 | Japan |
| Maeshima Rheumatology Clinic | Recruiting | Ōita | 870 0030 | Japan |
| Sanuki Municipal Hospital | Recruiting | Sanuki | 7692393 | Japan |
| Sasebo Chuo Hospital | Recruiting | Sasebo | 857 1195 | Japan |
| Tohoku University Hospital | Recruiting | Sendai | 980 8574 | Japan |
| Dokkyo Medical University Hospital | Recruiting | Shimotsuga Gun | 321 0293 | Japan |
| Kyorin University Hospital | Recruiting | Tokyo | 181 8611 | Japan |
| Mie University Hospital | Recruiting | Tsu | 514 8507 | Japan |
| National Hospital Organization Yokohama Medical Center | Recruiting | Yokohama | 245-8575 | Japan |
| Hospital Sultanah Bahiyah | Recruiting | Alor Star | 05460 | Malaysia |
| Hospital Selayang | Recruiting | Batu Caves | 68100 | Malaysia |
| Hospital Raja Permaisuri Bainun | Recruiting | Ipoh | 30450 | Malaysia |
| Hospital Sultan Ismail | Recruiting | Johor Bahru | 81100 | Malaysia |
| Hospital Kuala Lumpur | Recruiting | Kuala Lumpur | 50586 | Malaysia |
| Hospital Tuanku Jaafar | Recruiting | Seremban | 70300 | Malaysia |
| Centro de Investigacion de Tratamientos Innovadores de Sinaloa | Recruiting | Culiacán | 80000 | Mexico |
| Grupo Clinico CATEI | Recruiting | Guadalajara | 44630 | Mexico |
| Centro Medico del Angel | Recruiting | Mexicali | 45116 | Mexico |
| RM Pharma Specialists | Recruiting | Mexico City | 03100 | Mexico |
| Hospital Universitario Dr Jose Eleuterio Gonzalez | Recruiting | Monterrey | 64460 | Mexico |
| Centro de Alta Especialidad en Reumatologia e Investigacion | Recruiting | San Luis Potosí City | 78213 | Mexico |
| Osteo-Medic s.c A. Racewicz, J Supronik | Recruiting | Bialystok | 15-351 | Poland |
| Specderm Poznanska sp j | Completed | Bialystok | 15-375 | Poland |
| ClinicMed Daniluk Nowak Spolka Komandytowa | Recruiting | Bialystok | 15-879 | Poland |
| Szpital Uniwersytecki nr 2 im dr Jana Biziela w Bydgoszczy | Recruiting | Bydgoszcz | 85-168 | Poland |
| Ambulatorium sp. z o.o. | Recruiting | Elblag | 82-300 | Poland |
| Centrum Kliniczno Badawcze | Recruiting | Elblag | 82-300 | Poland |
| Centrum Medyczne Pratia Gdynia | Recruiting | Gdynia | 81-338 | Poland |
| Malopolskie Badania Kliniczne Sp z o o | Recruiting | Krakow | 30-002 | Poland |
| Specjalistyczny gabinet dermatologiczny Aplikacyjno Badawczy Marek Brzewski Pawel Brzewski Spolka Cywilna | Recruiting | Krakow | 30-002 | Poland |
| Centrum Medyczne All Med | Recruiting | Krakow | 30-033 | Poland |
| Pratia MCM Krakow | Recruiting | Krakow | 30-727 | Poland |
| Dermed Centrum Medyczne Sp z o o | Recruiting | Lodz | 90-265 | Poland |
| Zespol Poradni Specjalistycznych Reumed Filia nr 1 | Recruiting | Lublin | 20-607 | Poland |
| NZOZ Lecznica MAK MED S C | Recruiting | Nadarzyn | 05-830 | Poland |
| MICS Centrum Medyczne Torun | Recruiting | Torun | 87-100 | Poland |
| MICS Centrum Medyczne Warszawa | Recruiting | Warsaw | 00-874 | Poland |
| Centrum Medyczne Reuma Park | Recruiting | Warsaw | 02-665 | Poland |
| DermMedica Sp z o o | Recruiting | Wroclaw | 51-503 | Poland |
| Centrum Medyczne Oporow | Recruiting | Wroclaw | 52-416 | Poland |
| S C Delta Health Care S R L | Recruiting | Bucharest | 014142 | Romania |
| Ecomed Research SRL | Recruiting | Craiova | 200400 | Romania |
| Centrul Medical Unirea | Recruiting | Iași | 700259 | Romania |
| Medaudio Optica S R L | Recruiting | Râmnicu Vâlcea | 247065 | Romania |
| Hosp Univ A Coruna | Recruiting | A Coruña | 15006 | Spain |
| Hosp Reina Sofia | Recruiting | Córdoba | 14004 | Spain |
| Hosp. Univ. de Bellvitge | Recruiting | L'Hospitalet de Llobregat | 08907 | Spain |
| Hosp. Univ. Infanta Leonor | Recruiting | Madrid | 28031 | Spain |
| Hosp Regional Univ de Malaga | Recruiting | Málaga | 29009 | Spain |
| Hosp. Univ. Marques de Valdecilla | Recruiting | Santander | 39008 | Spain |
| Hosp. Clinico Univ. de Santiago | Recruiting | Santiago de Compostela | 15706 | Spain |
| Hosp. Virgen Macarena | Recruiting | Seville | 41009 | Spain |
| Hosp. Infanta Luisa | Recruiting | Seville | 41010 | Spain |
| Hosp. Virgen Del Rocio | Recruiting | Seville | 41013 | Spain |
| National Taiwan University Hospital Hsin Chu Branch | Recruiting | Hsinchu | 300 | Taiwan |
| Kaohsiung Chang Gung Memorial Hospital | Recruiting | Kaohsiung City | 83301 | Taiwan |
| Chi Mei Medical Center | Recruiting | Tainan | 710 | Taiwan |
| Taipei Veterans General Hospital | Recruiting | Taipei | 112 | Taiwan |
| Phramongkutklao Hospital | Recruiting | Bangkok | 10400 | Thailand |
| Rajavithi Hospital | Recruiting | Bangkok | 10400 | Thailand |
| Siriraj Hospital | Recruiting | Bangkok | 10700 | Thailand |
| Saraburi Hospital | Recruiting | Changwat Sara Buri | 18000 | Thailand |
| Songklanagarind hospital | Recruiting | Songkhla | 90110 | Thailand |
| Gulhane Egitim ve Arastirma Hastanesi | Recruiting | Ankara | 06010 | Turkey (Türkiye) |
| Gazi Universitesi Tip Fakultesi | Recruiting | Ankara | 06570 | Turkey (Türkiye) |
| Kocaeli University Medical Faculty | Recruiting | Kocaeli | 41001 | Turkey (Türkiye) |
| Necmettin Erbakan Universitesi Tip Fakultesi | Recruiting | Konya | 42080 | Turkey (Türkiye) |
| Royal Free London NHS Foundation Trust | Recruiting | Barnet | EN5 3DJ | United Kingdom |
| Basingstoke And North Hampshire Hospital | Recruiting | Basingstoke | RG24 9NA | United Kingdom |
| University Hospitals Dorset NHS Foundation Trust | Recruiting | Christchurch | BH23 2JX | United Kingdom |
| Western General Hospital | Recruiting | Edinburgh | EH4 2XU | United Kingdom |
| Glasgow Royal Infirmary | Recruiting | Glasgow | G31 2ER | United Kingdom |
| Hereford County Hospital | Recruiting | Hereford | HR1 2ER | United Kingdom |
| Forth Valley Royal Hospital | Recruiting | Larbert | FK5 4WR | United Kingdom |
| Haywood Hospital | Recruiting | Staffordshire | ST6 7AG | United Kingdom |
| Torbay Hospital-Devon | Recruiting | Torquay | TQ2 7AA | United Kingdom |
| New Cross Hospital | Recruiting | Wolverhampton | WV10 0QP | United Kingdom |
| Betsi Cadwaladr University Health Board BCUHB | Recruiting | Wrexham | LL13 7TD | United Kingdom |
| ID | Term |
|---|---|
| D015535 | Arthritis, Psoriatic |
| ID | Term |
|---|---|
| D025242 | Spondylarthropathies |
| D025241 | Spondylarthritis |
| D013166 | Spondylitis |
| D013122 | Spinal Diseases |
| D001847 | Bone Diseases |
| D009140 | Musculoskeletal Diseases |
| D001168 | Arthritis |
| D007592 | Joint Diseases |
| D011565 | Psoriasis |
| D017444 | Skin Diseases, Papulosquamous |
| D012871 | Skin Diseases |
| D017437 | Skin and Connective Tissue Diseases |
Not provided
Not provided