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The main aim of the study is to describe the possible impacts of SARS-CoV-2 and its various genotypes on pregnancy and long-term outcomes among pregnant women and their newborns in Estonia.
All the pregnant women in Estonia who conceived and gave birth between February 27, 2020, and March 1, 2023 were included in the study. Pregnant women will be divided into 2 groups: 1. pregnant women who were diagnosed with COVID-19 during the study period, along with their newborns; 2. control group: pregnant women who did not have COVID-19 during pregnancy, along with their newborns. The following data is collected for each subject: prior vaccination, previous COVID-19 infection, underlying diseases/conditions, hospitalization, need for intensive care, need for mechanical ventilation and/or oxygen therapy, death cases, post-COVID-19 symptoms, pregnancy course and outcomes, possible virus transmission from mother to child, and the newborn's condition or accompanying health issues
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Pregnant women with COVID-19 and their offspring | Pregnant women who were diagnosed with COVID-19 during the study period, along with their offspring |
| |
| Pregnant women who did not have COVID-19 and their offspring | Pregnant women who did not have COVID-19 during pregnancy, along with their offspring |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| COVID-19 infection | Other | COVID-19 diagnosis in the health database |
|
| Measure | Description | Time Frame |
|---|---|---|
| COVID-19 incidence | From enrollment to March 2023 | |
| Post-COVID condition incidence | From enrollment to March 2023 | |
| Chronic diseases incidence | From enrollment to March 2023 | |
| Newborn condition | Apgar scores at birth | From enrollment to March 2023 |
| Mortality | From enrollment to March 2023 | |
| Hospitalization rate due to COVID-19 | From enrollment to March 2023 | |
| Pregnancy complications incidence | From enrollment to March 2023 |
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Inclusion Criteria:
Exclusion Criteria:
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All the pregnant Estonian women who conceived and gave birth between February 27, 2020, and March 1, 2023
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Tartu | Tartu | Estonia |
The IPD collected throughout this trial will not be shared due to data protection laws.
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| ID | Term |
|---|---|
| D000086382 | COVID-19 |
| D000094024 | Post-Acute COVID-19 Syndrome |
| D000022 | Abortion, Spontaneous |
| ID | Term |
|---|---|
| D011024 | Pneumonia, Viral |
| D011014 | Pneumonia |
| D012141 | Respiratory Tract Infections |
| D007239 | Infections |
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| D014777 |
| Virus Diseases |
| D018352 | Coronavirus Infections |
| D003333 | Coronaviridae Infections |
| D030341 | Nidovirales Infections |
| D012327 | RNA Virus Infections |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D000094025 | Post-Infectious Disorders |
| D002908 | Chronic Disease |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D011248 | Pregnancy Complications |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |