A clinical study with approximately 40 subjects, aged 35-65 years of age, who must have crow's feet and at least one other type of facial fine lines/wrinkles in order to evaluate the efficacy of Activated Silk™ 27P-α to improve the signs of aging.

Inclusion Criteria:

• Healthy individuals, between the ages of 35 - 65 years of age, with no known medical conditions that interfere with study participation, are the priority.
• Subject has signed a written Informed Consent prior to Day -7.
• 100% of subjects have crow's feet and at least one of the following: forehead lines/wrinkles (e.g. vertical lines between eyebrows, horizontal lines above the eyebrow), marionette lines, nasolabial folds.
• 50% of subjects have self-perceived sensitive skin.
• 20% of the subjects are not 100% caucasian.

Exclusion Criteria:

• Subject is pregnant, nursing, or planning to become pregnant.
• Subject is currently using medication likely to affect the response to investigational formulation.
• Subject had a fever in the last 12 hours prior to the start of the study.
• Subject has a pacemaker or significant medical history of hepatic, renal, cardiac, pulmonary, digestive, hematological, neurological, locomotor or psychiatric disease; cancer; multiple sclerosis; high blood pressure; thrombosis; phlebitis (inflammation of a vein); insulin-dependent diabetes; or any such related medical condition(s) that may interfere with the completion of the study.
• The Subject used a form of retinol on their face in the past six months.
• The Subject used any prescription skincare products on their face in the last six months.
• The Subject has received any laser, chemical peel, or other facial resurfacing treatment such as microdermabrasion, dermablading or microneedling in the past four weeks.
• The Subject received Botox, Dysport, other muscle relaxers or injectable skin fillers in the face during the past six months.
• Subject has a known allergy or sensitivity to any ingredient in the aqueous skincare formulation provided for their use in the trial .
• Subject is currently participating in another study utilizing facial products.
• Subject is blind, visually impaired or decisionally impaired.