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The purpose of this study is to assess the electrophysiological mechanism of atrial fibrillation by means of a beat-to-beat noninvasive 3D mapping method in patients with concomitant persistent and long-standing persistent atrial fibrillation undergoing surgical ablation.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Electrocardiographic imaging | Device | Electrocardiographic imaging is an electrophysiological mapping technique which is used to noninvasively map cardiac arrhythmias. |
|
| Measure | Description | Time Frame |
|---|---|---|
| The patients electrophysiological mapping results acquired with ECGI will be analyzed: Number and distribution of rotor and focal activities will be measured. | The primary objective of this study is to measure the patients electrophysiological mapping results acquired with ECGI, namely the number and distribution of focal and rotor activities. | Prior to the planned procedure. |
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| Measure | Description | Time Frame |
|---|---|---|
| Freedom from AF during 12 and 24 months of follow-up. | A pre-specified outcome measure is to measure freedom from AF during 12 and 24 months of follow-up. The impact of the preoperative mapping results and the applied respective ablation technique will be analyzed. | From surgery until 24 months after the procedure. |
Inclusion Criteria:
Exclusion Criteria:
vulnerable patient groups
pregnancy
any previous surgical ablation
acute surgical indications
any physical condition that leads to a life expectancy of less than two years
any contraindication to the treatments necessary for the trial's conduction as e.g.
participation in any other clinical trial that either excludes enrolment or may be a confounding factor to results
voluntary retention
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Patients with persistent or long-standing persistent atrial fibrillation scheduled for concomitant surgical ablation at Vienna General Hospital of the Medical University of Vienna.
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| Name | Affiliation | Role |
|---|---|---|
| Emilio Osorio, MD | Medical University of Vienna | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Medical University of Vienna | Vienna | 1090 | Austria |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40828886 | Derived | Osorio-Jaramillo E, Conci L, Schloglhofer T, Coti I, Strassl A, Schukro C, Zimpfer D, Ehrlich MP, Ad N. Electrocardiographic Imaging as Preoperative Tool in Persistent and Long-Standing Persistent Atrial Fibrillation: A Prospective Observational Study. Interdiscip Cardiovasc Thorac Surg. 2025 Sep 1;40(9):ivaf198. doi: 10.1093/icvts/ivaf198. |
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IPD will be shared on reasonable request to the principal investigator.
From 03/2025 until 12/2025
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| ID | Term |
|---|---|
| D001281 | Atrial Fibrillation |
| ID | Term |
|---|---|
| D001145 | Arrhythmias, Cardiac |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D010335 | Pathologic Processes |
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| D013568 |
| Pathological Conditions, Signs and Symptoms |