Assessment of Multifocal Continuous Theta Burst Transcranial Magnetic Stimulation (cTBS) Effects in Generalized Epilepsy Patients.

Multifocal Theta Burst Transcranial Magnetic Stimulation in Generalized Epilepsy Management.

The goal of this clinical study is to assess the efficacy of multifocal theta burst transcranial magnetic stimulation in the prevention of epileptic seizures in adult patients with generalized epilepsy. The main questions it aims to answer are:

• How does multifocal continuous theta burst stimulation (cTBS) impact the frequency and severity of epileptic seizures?
• Does cTBS influence the quality of life in patients with generalized epilepsy?
• What is the safety and tolerability profile of the experimental multifocal cTBS protocol?

Inclusion Criteria:

- Adult patients with generalized epilepsy (according to ILAE 2017 classification of epilepsy).

Exclusion Criteria:

• refusal to sign the informed consent;
• focal, combined or unknown epilepsy (according to ILAE criteria);
• drug-resistant form of epilepsy (according to ILAE definition);
• history or symptoms of renal or hepatic failure;
• history of oncological disorder;
• uncontrolled high blood pressure;
• cognitive impairment;
• psychiatric disorders;
• signs of structural brain injury or focal neurological symptoms;
• use of opioids or muscle relaxants;
• history of substance abuse;
• ferromagnetic implants in head and neck regions;
• cardiac pacemakers;
• pregnancy or lactation.