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This study aims to investigate the association between the systemic immune-inflammation index and disease activity, as well as lupus nephritis in patients with systemic lupus erythematosus
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| patients diagnosed with systemic lupus and lupus nephritis | this group will include 30 patients, all patients will undergo the following: For the evaluation of SLE clinical disease activity SLEDAI ( systemic upus erythematosus disease activity index)scores will be recorded The SII (systemic immune inflammatory index) will be calculatedusing the following formula: SII = (neutrophil count × platelet count)/lymphocyte count. |
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| patients diagnosed with systemic lupus without lupus nephritis | this group will also include 30 patients, all patients will undergo the following: For the evaluation of SLE clinical disease activity SLEDAI ( systemic upus erythematosus disease activity index)scores will be recorded The SII (systemic immune inflammatory index) will be calculated using the following formula: SII = (neutrophil count × platelet count)/lymphocyte count. |
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| healthy control group | this group will also include 30 healthy controls , they will undergo the following: The SII (systemic immune inflammatory index) will be calculated using the following formula: SII = (neutrophil count × platelet count)/lymphocyte count. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| systemic immune inflammatory index | Diagnostic Test | Systemic immune inflammatory index (SII) is a combination of three hematological parameters (platelets, neutrophils, and lymphocytes) and it is calculated using the following formula: SII = (neutrophil count × platelet count)/lymphocyte count. |
| Measure | Description | Time Frame |
|---|---|---|
| association of systemic immune-inflammation index (SII) disease activity in systemic lupus erythematosus | This study aims to investigate if there is an association between the systemic immune-inflammation index (SII) and disease activity in patients with systemic lupus erythematosus using SLEDAI(systemic lupus erythematosus disease activity index) as a valid index to compare results with | baseline |
| association of systemic immune-inflammation index (SII) and lupus nephritis in patients with systemic lupus erythematosus | This study aims to investigate the association between the systemic immune-inflammation index (SII) and lupus nephritis in patients with systemic lupus erythematosus | baseline |
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Inclusion Criteria:
o Older than 16 years
Exclusion Criteria:
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patients attending in rheumatology outpatient clinic, sohag university hospital
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Shorouk Mohamed abdelmageed, master degree | Contact | 02 +01099082079 | Shrouk011107@med.sohag.edu.eg |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Sohag Faculty | Recruiting | Sohag | Sohag Governorate | 1670005 | Egypt |
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| ID | Term |
|---|---|
| D008180 | Lupus Erythematosus, Systemic |
| D008181 | Lupus Nephritis |
| ID | Term |
|---|---|
| D003240 | Connective Tissue Diseases |
| D017437 | Skin and Connective Tissue Diseases |
| D001327 | Autoimmune Diseases |
| D007154 | Immune System Diseases |
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| D005921 | Glomerulonephritis |
| D009393 | Nephritis |
| D007674 | Kidney Diseases |
| D014570 | Urologic Diseases |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |