Observational clinical follow-up to evaluate the safety of immunotherapy for the treatment of hymenoptera venom allergy in real-life conditions. It includes the evaluation of controlled and spontaneous stings. This study will be conducted in Spain (multicentric), multicentric and data will be collected prospectively.

Observational, multicentric (Spain), prospective study and data will be collected properly. The total number of participants is expected to be 80. The patients aged equal or more than 14 years old, sentitized to himenoptera venom, not gender differentiation.

Inclusion Criteria:

• The study population consisted of allergic participants indicated for treatment with hymenoptera venom immunotherapy (Apis mellifera or Vespula spp.) according to standard clinical practice.
• Participants of both sexes aged 14 years or more.
• Participants who have not received immunotherapy with hymenoptera venom in the previous 5 years.
• Participants who have agreed to take part in the study and sign the informed consent form. In the case of minors, the patient's parent or guardian must also sign.

Exclusion Criteria:

• Pregnant or breastfeeding women.
• Having received immunotherapy with hymenoptera venom during the 5 years prior to the start of the study.
• Participants who do not agree to participate and/or do not sign the informed consent form.
• Participants who do not comply with medical indications or do not cooperate with immunotherapy treatment.

Participants of both gender aged 14 years or more diagnosed of allergy to Apis mellifera and/or Vespula spp. venom, susceptible to receive ITVH according to standard clinical practice.