F-18 FDG PET/CT and CT in Initial Staging of Non-small Lung Cancer

Comparison of F-18 FDG PET/CT and CT in Initial Staging of Non-small Lung Cancer

Is to compare F-18 FDG PET/CT to routine CT in staging of non-small lung cancer and effect on change management.

• The optimal treatment of non-small cell lung cancer (NSCLC) relies on accurate disease staging that is based on the TNM system which relies on tumor size, regional nodal involvement, and the presence of metastasis.
• CT is the standard modality used to assess the intra-thoracic spread but false negative CT scans have been reported and were related to the presence of metastasis in normal sized lymph nodes and false positive findings have been related to lymph node enlargement due to benign process.

PET is most widely used in thoracic oncology because of its superiority over other imaging techniques in staging nodal and metastatic disease, however, the poor anatomic details of PET can lead to errors in diagnosis and staging.

• To solve this problem, CT is combined with PET to provide matched morphological and functional data. The diagnostic capability of PET/CT in the preoperative staging of lung cancer is superior to that of CT alone and PET alone as it has the advantage of a more accurate assignment of tumor stage (T stage) and defining the lymph node stage (N stage) as well as reduction of the number of useless thoracotomies

Inclusion Criteria:

• Patients with pathologically proven NSCLC who underwent initial PET/CT images.
• All patients ≥ 18 years.

Exclusion Criteria:

• Patients who had started treatment before initial PET/CT. Patients with glucose level < 200 mg/dl. Patients with another malignant condition.