Dynamic Cardio-vascular, Cerebro-vascular and Cortical Interaction in Healthy Adult Subjects

Dynamic Cardio-, Cerebro-vascular and Cortical Interaction in Healthy Adult Subjects

IDEALE aims to assess the status of autonomic function, cerebral autoregulation (CA) and cortical activity in healthy subjects and correlate these functions with the psychological dimension of the subjects.

To this end, parameters of cardiac, cortical, vascular and cerebrovascular variability derived from electrocardiographic, electroencephalographic, respiratory movement, blood pressure, transcranial Doppler signals will be acquired and analysed for each healthy volunteer (TCD) and Laser-Doppler transcutaneous, during a phase of clinostatism (REST) and one of active orthostatism (STAND). In addition, volunteers will be submitted to psychometric tests (Chieti Affective Action Videos, CAAV) to assess the presence of depressive symptoms.

Inclusion Criteria:

• age older than 18 years
• spontaneous sinus rhythm
• signed informed consent

Exclusion Criteria:

• Definite diseases of the Autonomic Nervous System (SNA) or the cardiovascular system
• Central nervous system disorders
• subjects under drug therapy that may affect the cardiovascular system
• pregnancy
• previous diagnosis of depression