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Cerebral haemorrhage represents a minority of acute vascular syndromes (less frequent than ischemic stroke, at around 20%), but with a therapeutic impasse, having no specific treatment.
Arterial contrast ("spot sign") within the hematoma has been described in CT scans as a risk factor for further enlargement and poor prognosis.
An equivalent marker has also been described in gadolinium-enhanced MRI.
By studying the radiological appearance of gadolinium "spot signs" on MRI, which has better parenchymal resolution, the researchers propose to retrace the phenomenology of the acute phase of cerebral hemorrhage in order to better estimate the risk of radiological aggravation by subgroup, which could serve as a target population for future therapeutic trials.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| patients with acute lobar and deep haematoma | None, pure observational study |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| None, pure observational study | Other | None, pure observational study |
|
| Measure | Description | Time Frame |
|---|---|---|
| Presence of spot sign on gadolinium MRI | Presence of spot sign on gadolinium MRI (Yes/No) | baseline |
| Morphologic description of gadolinium MRI spot sign | morphological (shape, location within the hematoma) description of spot signs on brain MRI | baseline |
| Quantitative description of gadolinium MRI spot sign | Quantitative (number and categorial) description of spot signs on brain MRI | baseline |
| Measure | Description | Time Frame |
|---|---|---|
| association of spot sign with hematoma expansion on follow-up CT | association of spot sign with hematoma expansion on follow-up CT(Yes/No) | Baseline |
| Association with the underlaying pathology |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with acute cerebral hematoma from existing databases of cerebral amyloid angiopathy and hypertensive microangiopathy; who underwent a follow-up cerebral CT scan in the event of worsening or for follow-up.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Teodora PARVU | Contact | 04.66.68.32.61 | teodora.parvu@chu-nimes.fr |
| Name | Affiliation | Role |
|---|---|---|
| Anissa MEGZARI | Centre Hospitalier Universitaire de Nīmes | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU de Nîmes | Recruiting | Nîmes | Gard | 30029 | France |
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| ID | Term |
|---|---|
| D002543 | Cerebral Hemorrhage |
| ID | Term |
|---|---|
| D020300 | Intracranial Hemorrhages |
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
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Association with the underlaying pathology as identified by the authors (Yes/No)
| Baseline |
| D009422 | Nervous System Diseases |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D006470 | Hemorrhage |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |