The primary objective of this study is to assess the safety of the 3D Transcranial Ultrasound Brain Imaging (3D TRUBI) device in Traumatic Brain Injury (TBI) patients with intracranial hemorrhage (ICH). The secondary objective is to assess the diagnostic potential of 3D TRUBI. The latter will be achieved by comparison of 3D TRUBI scans with admission head computed tomography (CT), the standard of care diagnostic modality. Demonstrating the feasibility and safety of the 3D TRUBI system is the first step toward expanding access of an alternative to CT for diagnostic imaging and triage of mass casualties of war or natural disasters in the field and in rapidly deployed medical centers or other austere environments.

Eligible participants positive for intracranial hemorrhage (ICH) due to traumatic brain injury (TBI) will undergo a full scanning procedure by trained investigators. Examination with the 3D TRUBI system will involve acquisition of 16 pre-defined bilateral head points. The total time to complete the procedure is approximately 20 minutes. During the examination, feasibility and safety metrics will be collected. Additional injury data will be reviewed from participants' electronic medical record. The goal of the study is 1) to evaluate the safety of the 3D TRUBI device in the target population and 2) do demonstrate the feasibility of the device to detect ICH compared to standard medical imaging.

Inclusion Criteria:

• Age 18-89
• Acute head injury with CT-confirmed intracranial hemorrhage
• Able to obtain written, informed consent from participant or legally authorized representative
• Able to receive intervention within 4 hours of admission head CT
• Able to feasibly receive intervention prior to neurosurgical indication

Exclusion Criteria:

• Did not receive routine head CT
• Prisoner or Wards of State
• Large or open skull wounds prohibiting ultrasound acquisition
• Received large volume fluid resuscitation (e.g. >3 units of blood product) within 2 hours of intervention
• Any prohibiting condition or contraindication for ultrasound image acquisition

Participants will be recruited from qualifying Traumatic Brain Injuries accepted for care at Brooke Army Medical Center

To minimize risk of breaching confidentiality, individual data will not be shared with other researchers. Aggregate data may be shared upon reasonable request.