Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
This study is designed to test two new risk scores - one designed to predict a patient's four-hour risk of developing sepsis and one designed to predict a patient's four-hour risk of deterioration (cardiac arrest, death, unplanned ICU transfer, or rapid response team call). The goal of this study is to improve provider awareness of a patient's risk of these two negative outcomes by providing them with new risk scores. The primary outcome will be the time from when the risk score becomes elevated to when vital signs such as heart rate or blood pressure are measured, suggesting an increased awareness.
The University of Maryland Medical System is conducting a study designed to test two new risk scores - one designed to predict a patient's four-hour risk of developing sepsis and one designed to predict a patient's four-hour risk of deterioration (death, cardiac arrest, unplanned ICU transfer, or rapid response call). The goal of this study is to improve provider awareness of a patient's risk of these two negative outcomes, sepsis and deterioration, by providing them with new risk scores. To assess provider awareness of risk, this study will measure time from elevated risk score to measurement of vital signs, such as heart rate or blood pressure with the hope that increased awareness of risk will decrease time to vital sign measurement, indicating closer monitoring.
The first risk score, the RESCUE Score, produces a highly accurate 1-4 color-coded risk score where a 1 indicates that a patient has a low risk of having a deterioration event in the next four hours and a 4 indicates that the patient has a high risk of having a deterioration event in the next four hours. The second risk score, the SEPSys Score, produces a highly accurate 1-4 color coded risk score where 1 indicates that a patient has a low risk of developing sepsis in the next 4 hours and a 4 indicates that the patient has a high risk of developing sepsis in the next 4 hours. Both of these scores are predictive of events that may happen in the future but are not detective or diagnostic of events that are actively occurring.
In this study, hospitals will be randomized for the order in which they cross-over from the control arm (no risk score) to either having the SEPSys or RESCUE Score visible for their inpatients. After a few months with an individual risk score, the second risk score will be added. Thus, at the beginning of the study, no hospitals with have the new risk scores available, for a period in the middle of the study each hospital will have one risk score available, and by the end of the study all hospitals will have both risk scores available. Regardless of which risk scores are available, the clinicians will be free to recommend treatments and implement care plans using their own judgement. No procedures impacting patient care will be specified for this study.
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| SEPSys | Experimental | Cluster has SEPSys Score only |
|
| RESCUE | Experimental | Cluster has RESCUE Score only |
|
| SEPSys+RESCUE | Experimental | Cluster has both SEPSys & RESCUE Scores |
|
| Baseline | No Intervention | Cluster has neither SEPSys nor RESCUE |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| SEPSys | Device | The SEPSys Score is a clinical decision support tool for predicting the risk of developing sepsis in the next 4 hours. The SEPSys Score produces a 1-4, color-coded risk, where 4 (red) is the highest risk and 1 (green) is the lowest risk. |
| Measure | Description | Time Frame |
|---|---|---|
| Time To Vital Sign Measurement | Time to vital sign measurement after elevation of either the Sepsis Early Prediction System (SEPSys) or RESCUE Score. An elevated SEPSys or RESCUE Score is defined as a current SEPSys or RESCUE Score of 3 or 4 (highest risk) when the previous Score was a 1 (lowest risk) or 2. | From time of elevation of either the Sepsis Early Prediction System (SEPSys) or RESCUE Score to measurement of vital signs, assessed continually during the hospitalization (up to 24 hours after the elevation)). |
| Measure | Description | Time Frame |
|---|---|---|
| Sepsis diagnosis | The patient develops sepsis during the hospitalization following elevation of the SEPSys score. An elevated SEPSys or RESCUE Score is defined as a current SEPSys or RESCUE Score of 3 or 4 (highest risk) when the previous Score was a 1 (lowest risk) or 2. | Beginning at time of hospital admission and assessed continually until hospital discharge (average of 5 days). |
Not provided
Hospital Unit Inclusion Criteria:
General Encounter Inclusion Criteria:
Additional SEPSys Encounter Inclusion Criteria:
• Encounter has a SEPSys Score
Additional RESCUE Encounter Inclusion Criteria:
• Encounter has a RESCUE Score
Exclusion Criteria:
Hospital Unit Exclusion Criteria:
Additional SEPSys Encounter Exclusion Criteria:
This encounter will have been eligible until the patient began showing clinical signs or symptoms of sepsis or received a diagnosis of sepsis. Once they have a diagnosis or clinical signs or symptoms of sepsis, their SEPSys Score will no longer be updated. Data will continue to be collected on time of laboratory orders and treatments.
Additional RESCUE Encounter Exclusion Criteria:
• Encounter is admitted with a high RESCUE Score (RESCUE Score of 4)
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Samuel A Tisherman, MD | Contact | 410-328-9114 | stisherman@som.umaryland.edu | |
| Jason Heavner, MD | Contact | 410-553-8240 | jason.heavner@umm.edu |
Not provided
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Maryland Medical Center - Midtown | Recruiting | Baltimore | Maryland | 21201 | United States | |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D018805 | Sepsis |
| ID | Term |
|---|---|
| D007239 | Infections |
| D018746 | Systemic Inflammatory Response Syndrome |
| D007249 | Inflammation |
| D010335 | Pathologic Processes |
Not provided
Not provided
This is a 2-intervention + control cluster-randomized factorial stepped wedge design clinical trial
Not provided
Not provided
Not provided
| RESCUE | Device | The RESCUE Score is a clinical decision support tool for predicting the risk of patient experiencing clinical deterioration (cardiac arrest, rapid response team call, death, or unplanned increase in care) in the next 4 hours. The RESCUE Score produces a 1-4, color-coded risk, where 4 (red) is the highest risk and 1 (green) is the lowest risk. |
|
| Time to sepsis-specific treatment | Time from first elevated SEPSys Score to order/administration of sepsis indicated antibiotics or fluid bolus. An elevated SEPSys or RESCUE Score is defined as a current SEPSys or RESCUE Score of 3 or 4 (highest risk) when the previous Score was a 1 (lowest risk) or 2. | From time of elevation of the SEPSys Score to initiation of sepsis-specific antibiotics or fluid bolus, assessed continually during the hospitalization (up to 96 hours). |
| Deterioration Events | Binary outcome of deterioration event (cardiac arrest, death, rapid response team call, unplanned increase in level of care). An elevated SEPSys or RESCUE Score is defined as a current SEPSys or RESCUE Score of 3 or 4 (highest risk) when the previous Score was a 1 (lowest risk) or 2. | Beginning at time of hospital admission and assessed continually until hospital discharge (average of 5 days). |
| Frequency of laboratory orders | Frequency of laboratory orders or measurements after an elevated SEPSys or RESCUE Score. An elevated SEPSys or RESCUE Score is defined as a current SEPSys or RESCUE Score of 3 or 4 (highest risk) when the previous Score was a 1 (lowest risk) or 2. | From time of elevation of either the Sepsis Early Prediction System (SEPSys) or RESCUE Score to measurement of laboratory orders, assessed continually during the hospitalization (up to 24 hours). |
| University of Maryland Medical Center |
| Not yet recruiting |
| Baltimore |
| Maryland |
| 21201 |
| United States |
| University of Maryland Upper Chesapeake Medical Center | Not yet recruiting | Bel Air | Maryland | 21014 | United States |
| University of Maryland Shore Medical Center | Not yet recruiting | Easton | Maryland | 21601 | United States |
| University of Maryland Baltimore Washington Medical Center | Not yet recruiting | Glen Burnie | Maryland | 21061 | United States |
| University of Maryland Charles Regional Medical Center | Not yet recruiting | La Plata | Maryland | 20646 | United States |
| University of Maryland Capital Region Medical Center | Recruiting | Largo | Maryland | 20774 | United States |
| University of Maryland St. Joseph Medical Center | Not yet recruiting | Towson | Maryland | 21204 | United States |
| D013568 |
| Pathological Conditions, Signs and Symptoms |