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Emergency neurology covers a wide range of conditions, often involving urgent situations such as acute cerebrovascular diseases, seizures, central nervous system infections, and consciousness disorders. However, due to the time constraints in emergency care and limited patient information collection, misdiagnosis and missed diagnoses are common issues. Large language models (LLMs) possess powerful natural language processing and knowledge reasoning capabilities, enabling them to directly handle and understand complex, unstructured medical data such as patient medical records, dialogue notes, and laboratory test results. LLMs show broad potential for application in complex medical scenarios. This study aims to evaluate the application value of LLMs in emergency neurology, specifically examining their diagnostic accuracy in emergency neurology conditions, analyzing the feasibility of treatment plans and further examination recommendations proposed by the model, and exploring their potential in improving diagnostic efficiency and aiding decision-making.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients presenting to the emergency neurology department. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Large Language Model Diagnosis | Diagnostic Test | Using the large language model for diagnosing emergency neurology conditions. |
|
| Measure | Description | Time Frame |
|---|---|---|
| dignostic accuracy | To evaluate the consistency between the diagnosis made by large language models for emergency patients and the confirmed diagnosis after inpatient or outpatient visits. | 1 month |
| Measure | Description | Time Frame |
|---|---|---|
| Feasibility of treatment plans | Experts use the Emergency Treatment Recommendation Scoring Scale to evaluate the treatment suggestions from conventional methods and large language models. The maximum score is 5 and the minimum score is 1, with 5 representing strong agreement with the recommendation. | 1 month |
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Inclusion Criteria:
Exclusion Criteria:
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Patients in the emergency neurology department
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Xuanwu Hospital, Capital Medical University | Beijing | Beijing Municipality | 100053 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 42000879 | Derived | Guo Y, Meng X, Yu E, Zhang W, Yang Y, Ma H, Shao C, Wang W, Wang R, Wang H, Meng R, Zhao W, Song Z, Ji X, Wu C. Development and prospective shadow evaluation of a domain-specific large language model for emergency neurological diagnosis. NPJ Digit Med. 2026 Apr 18;9(1):470. doi: 10.1038/s41746-026-02644-z. |
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| ID | Term |
|---|---|
| D004630 | Emergencies |
| ID | Term |
|---|---|
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| dignostic specificity |
A comparison of dianostic specificity between large language model diagnosis and emergency department physicians diagnosis |
| 1 month |
| Diagnostic Sensitivity | A comparison of dianostic sensitivity between large language model diagnosis and emergency department physicians diagnosis. | 1 month |
| False Discovery Rate | A comparison of the false discovery rate between large language model diagnosis and emergency department physicians diagnosis. | 1 month |