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| Name | Class |
|---|---|
| Jiangsu Cancer Institute & Hospital | OTHER |
| The Affiliated Tumor Hospital of Nantong University, Nantong, Jiangsu Province, China | OTHER |
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Gastric cancer is one of the most common malignancies of the gastrointestinal system, especially in East Asia. A host of patients are diagnosed with GC at the late stage, leading to poor patient prognosis. Therefore, there is a strong demand to develop new biomarkers to detect this tumor early. Small non-coding RNA species include microRNA (miRNA), PIWI-interacting RNA (piRNA), small interfering RNA (siRNA), tRNA-derived small RNA (tsRNA), etc. It has been demonstrated that small non-coding RNAs are involved in gastric cancer cell proliferation, metastasis, progression and survival. Hence, it is considered as an auxiliary diagnostic biomarker for gastric cancer.
Gastric cancer is one of the most common malignancies of the gastrointestinal system, especially in East Asia. A host of patients are diagnosed with GC at the late stage, leading to poor patient prognosis. Therefore, there is a strong demand to develop new biomarkers to detect this tumor early.
Small non-coding RNA species include microRNA (miRNA), PIWI-interacting RNA (piRNA), small interfering RNA (siRNA), tRNA-derived small RNA (tsRNA), etc. It has been demonstrated by previous scientific researches that small non-coding RNAs are involved in gastric cancer cell proliferation, metastasis, progression and survival. Hence, it is considered as a new biomarker panel for gastric cancer.
The purpose of the present clinical trail is to explore the correlation between small non-coding RNAs panel and early gastric cancer, and to elucidate the possibility of small non-coding RNAs panel as a biomarker for gastric cancer. Verify the experimental purpose by monitoring the relative quantification of small non-coding RNAs panel through high-throughput sequencing and qRT PCR technology.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Gastric cancer cases from medical centers in China | Measurement of levels of circulating small non-coding RNAs |
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| Controls from medical centers in China | Measurement of levels of circulating small non-coding RNAs |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Analysis of relative quantitative of small non-coding RNAs | Diagnostic Test | Each participant was enrolled to assess the of relative quantitative of small non-coding RNAs |
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| Measure | Description | Time Frame |
|---|---|---|
| Analysis of relative quantitative of small non-coding RNAs | Relative quantitative of small non-coding RNAs are detected by quantitative RT-PCR | an average of 2 years |
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Inclusion Criteria:
Exclusion Criteria:
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AFFILIATED HOSPITAL OF NANTONG UNIVERSITY
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Affiliated Hospital of Nantong University | Nantong | Jiangsu | 226001 | China |
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| ID | Term |
|---|---|
| D013274 | Stomach Neoplasms |
| ID | Term |
|---|---|
| D005770 | Gastrointestinal Neoplasms |
| D004067 | Digestive System Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
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| D004066 |
| Digestive System Diseases |
| D005767 | Gastrointestinal Diseases |
| D013272 | Stomach Diseases |