Whipple's disease (WD), a rare systemic infection by Tropheryma whipplei, lacks research on biological abnormalities pre- and post-treatment. This study explores these abnormalities for their diagnostic and monitoring value.

Whipple's disease (WD) is a rare systemic infection caused by *Tropheryma whipplei*. Despite advancements in diagnosis through PCR and biopsy, there is limited research comparing biological abnormalities before and after treatment. This study aimed to characterize these abnormalities and evaluate their potential for aiding in diagnosis and monitoring.

Inclusion Criteria:

• Patients with at least one positive PCR test for Whipple's disease and a retained diagnosis at Brest University Hospital between 2010 and 2024
• Major patient

Exclusion Criteria:

• Minors
• No screening test for Whipple's disease
• Opposition to participation
• Protected patients

Retrospective study of patients hospitalised in Brest who tested positive for Whipple's disease between 2010 and 2024

All collected data that underlie results in a publication

Data will be available beginning three years and ending fifteen years following the final study report completion

Data access requests will be reviewed by the internal committee of Brest UH. Requestors will be required to sign and complete a data access agreement