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| Name | Class |
|---|---|
| The First Affiliated Hospital of Zhengzhou University | OTHER |
| Second Hospital of Shanxi Medical University | OTHER |
| Sir Run Run Shaw Hospital | OTHER |
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The goal of this observational study was to learn about the long-term clinical efficacy of conservative treatment in atlantoaxial dislocation patients without neurological deficit. The main question it aims to answer is:
Is surgical intervention always necessary in atlantoaxial dislocation patients without nerve deficit?
Patients who refuse surgical intervention will continue to be treated conservatively. Clinical outcomes will be summarized over five years of follow-up
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Conservative Treatment Group | Patients who declined surgery and request conservative treatment and observation. | ||
| Surgical Intervention Group | Patients who request surgical intervention. |
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| Measure | Description | Time Frame |
|---|---|---|
| The incidence of neurological deficit | The incidence of neurological deficit is defined as the proportion of patients with neurological deficit to the total number of patients during the research period. Neurological deficit includes cranial nerve involvement and spinal cord involvement, with specific clinical manifestations such as occipital neuralgia, dysphagia, dysarthria, nystagmus, unsteadiness in holding objects, unsteady gait, decreased limb muscle strength, paralysis, and others. | The incidence of neurological deficit will be assessed at the initial visit, and at 3 months, 6 months, and 12 months after the initial visit, with annual follow-ups thereafter. Follow-up will continue for at least 5 years. |
| Measure | Description | Time Frame |
|---|---|---|
| Japanese Orthopaedic Association score | The Japanese Orthopaedic Association (JOA) score is a widely used disease-specific outcome tool that can provide a quantitative measure for patients with cervical myelopathy. JOA score consists of 6 domains: motor function in upper extremities, motor function in lower extremities, sensory function in upper extremities, sensory function in the trunk, sensory function in lower extremities, and bladder function, with a minimum total score of 0 and maximum of 17. |
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Inclusion Criteria:
Exclusion Criteria:
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Atlantoaxial dislocation patients without neurological deficit.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Shenglin Wang, M.D. | Contact | +8613501380281 | pkuwsl@126.com | |
| Zhihang Gan, M.B. | Contact | +8618786004556 | 2010301328@stu.pku.edu.cn |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Peking University Third Hospital | Beijing | Beijing Municipality | 100191 | China |
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| Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University |
| OTHER |
| Hebei Medical University Third Hospital | OTHER |
| Shanxi Bethune Hospital | OTHER |
| Daping Hospital of Army Medical University | OTHER |
| Shengjing Hospital | OTHER |
| Tianjin People's Hospital | OTHER |
| First Affiliated Hospital of Kunming Medical University | OTHER |
| Guilin Medical University, China | OTHER |
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No samples will be retained.
| The JOA score will be assessed at the initial visit, and at 3 months, 6 months, and 12 months after the initial visit, with annual follow-ups thereafter. Follow-up will continue for at least 5 years. |
| Neck Disability Index | The Neck Disability Index (NDI) is the most widely used assessment tool measuring disability due to neck pain or neck injury. The NDI consists of 10 items: pain intensity, personal care, lifting, reading, headaches, concentration, work, driving, sleeping and recreation. The total score for the NDI is out of 50. A higher total score indicates a higher level of disability. | The NDI will be assessed at the initial visit, and at 3 months, 6 months, and 12 months after the initial visit, with annual follow-ups thereafter. Follow-up will continue for at least 5 years. |
| ADI | Atlantodental Interval (ADI) refers to the distance between the anterior tubercle of the atlas and the odontoid process, which reflects the severity of atlantoaxial dislocation. | The ADI will be assessed at the initial visit, and at 3 months, 6 months, and 12 months after the initial visit, with annual follow-ups thereafter. Follow-up will continue for at least 5 years. |