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| ID | Type | Description | Link |
|---|---|---|---|
| K01AG075180 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Institute on Aging (NIA) | NIH |
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In older adults, diminished sensation of the legs and feet is highly prevalent and causes poor balance and reduced mobility. This type of sensation is not only dependent upon the receptors and nerves in the legs and feet, but also upon a complex central nervous system pathway that includes the cerebral cortex of the brain. This project will use a form of noninvasive brain stimulation called transcranial direct current stimulation (tDCS) to test whether increasing the excitability of the brain networks that process sensory feedback can augment foot sole sensation, balance, and mobility in older adults suffering from mild-to-moderate foot sole sensory impairments.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| tDCS group | Experimental | Participants in this arm will receive the real tDCS intervention. |
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| sham group | Sham Comparator | Participants in this arm will receive the sham stimulation as control. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| transcranial direct current stimulation | Device | tDCS can safely and selectively modulate cortical excitability (specifically neuronal firing likelihood) by transferring weak electrical currents between scalp electrodes. The direct current delivered by any one electrode will not exceed 2.0 mA and the total amount of current from all electrodes will not exceed 4 mA in this study. |
| Measure | Description | Time Frame |
|---|---|---|
| postural sway area when standing with eyes closed on the foam | This metric assesses the degree to which the soft support and cut-off of the vision diminishes the control of standing posture. | Before and immediately after intervention |
| Timed Up-and-Go (TUG) time | This metric assesses mobility. | Before and immediately after intervention |
| On-target Blood oxygen level dependent (BOLD) signal intensity in response to foot sole stimulation | This metric assesses the degree to which brain cortical regions activated by the walking-related foot-sole stimulation. | Before and immediately after intervention |
| Standing vibratory thresholds of each foot sole | This metric assesses the degree to which the foot soles can sense the vibro-tactile stimuli when standing. | Before and immediately after intervention |
| Measure | Description | Time Frame |
|---|---|---|
| Postural sway speed when standing with eyes closed on the foam | This metric assesses the degree to which the soft support and cut-off of the vision diminishes the control of standing posture. | Before and immediately after intervention |
| Gait speed of 10m walking test |
| Measure | Description | Time Frame |
|---|---|---|
| BOLD signal intensity within other relevant cortical regions in response to foot sole stimulation | This metric assesses the degree to which brain cortical regions activated by the walking-related foot-sole stimulation. | Before and immediately after intervention |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Junhong Zhou, PhD | Contact | 617-971-5346 | junhongzhou@hsl.harvard.edu |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hebrew SeniorLife | Recruiting | Roslindale | Massachusetts | 02131 | United States |
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| ID | Term |
|---|---|
| D065908 | Transcranial Direct Current Stimulation |
| ID | Term |
|---|---|
| D004599 | Electric Stimulation Therapy |
| D013812 | Therapeutics |
| D003295 | Convulsive Therapy |
| D013000 | Psychiatric Somatic Therapies |
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| active sham stimulation | Device | sham stimulation will implement the same protocol of the tDCS intervention; however, only very low-level currents (no more than 0.5 mA) are transferred between the same electrodes used for the tDCS throughout the 20-minute session. This strategy effectively mimics the cutaneous sensations and skin redness induced by creating only micro cortical electric fields. |
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This metric assesses mobility. |
| Before and immediately after intervention |
| D004191 | Behavioral Disciplines and Activities |
| D004597 | Electroshock |
| D011580 | Psychological Techniques |