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| ID | Type | Description | Link |
|---|---|---|---|
| R01AG088083 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Institute on Aging (NIA) | NIH |
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The purpose of this study is to identify which supplemental intervention components added to an online exercise program contribute to the greatest increases in physical activity (total MVPA and percent meeting guidelines [≥150 min/week of MVPA]) in adults with knee replacement at 6 and 12 months. Secondary outcomes will examine changes in pain and physical function.
All participants will receive a 6-month, fully automated online behavioral exercise program (Energize! Exercise Program). This program is designed to increase moderate-intensity physical activity among individuals who engage in little to no physical activity at baseline. Over the course of the program, participants are given a physical activity goal which starts at 75 minutes per week and gradually progresses to 200 minutes per week. Participants are instructed to view a 10-15-minute video lesson weekly, during months 1-3, and monthly during months 4-6. These lessons teach behavioral principles for increasing exercise and maintaining physical activity long-term. Participants are also asked to complete an 'Apply Your Knowledge' activity after watching each video lesson. These activities are designed to help the participant engage more with the lesson content, with a particular emphasis on applying the content to their lives. Within this program, participants are also asked to plan and report their exercise each week, and automated feedback is provided based upon their weekly physical activity reports.
In addition to receiving the Energize! Exercise Program, participants will be randomly assigned to receive 0-4 supplemental intervention components (phone coaching, progress reports to providers, 'Hear From Others' videos, and individualized feedback) which are each described in more detail below.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Experimental condition 1 | Experimental | Energize Online Program plus phone coaching, progress reports to physicians, 'Hear From Others' videos, and individualized feedback |
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| Experimental condition 2 | Experimental | Energize Online Program plus phone coaching, progress reports to physicians, and 'Hear From Others' videos |
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| Experimental condition 3 | Experimental | Energize Online Program plus phone coaching, progress reports to physicians, and individualized feedback |
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| Experimental condition 4 | Experimental | Energize Online Program plus phone coaching and progress reports to physicians |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Phone Coaching | Behavioral | Participants will receive 11 coaching calls with a health coach. Calls will occur weekly during the first month, twice/month during months 2-3, and once/month during months 4-6. Each call is expected to last 10-15 minutes. |
| Measure | Description | Time Frame |
|---|---|---|
| Physical activity (min/week) | Change in Actigraph-assessed moderate-to-vigorous intensity physical activity | Baseline to 6 months |
| Percentage meeting physical activity guidelines | Percentage of participants meeting physical activity guidelines (150 minutes/week) | 6 months |
| Physical activity (min/week) | Change in Actigraph-assessed moderate-to-vigorous intensity physical activity | Baseline to 12 months |
| Percentage meeting physical activity guidelines | Percentage of participants meeting physical activity guidelines (150 minutes/week) | 12 months |
| Measure | Description | Time Frame |
|---|---|---|
| Pain intensity | Change in pain intensity using Patient-Reported Outcomes Measurement Information System (PROMIS) | Baseline to 6 months |
| Physical Function | Change in physical function using the physical function/mobility Patient-Reported Outcomes Measurement Information System (PROMIS) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Jakob Nelson, MS | Contact | 803-766-6960 | JAKOBRN@email.sc.edu | |
| Christine Pellegrini, PhD | Contact | 803-777-0911 | pellegca@mailbox.sc.edu |
| Name | Affiliation | Role |
|---|---|---|
| Christine Pellegrini, PhD | University of South Carolina | Principal Investigator |
| Jessica Unick, PhD | The Miriam Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of South Carolina | Recruiting | Columbia | South Carolina | 29208 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41845290 | Derived | Kennerley CL, Coffman DL, Kim Y, Nelson J, Jackson JB 3rd, Jamieson S, Horn K, Stansbury ML, Wilson-Barthes M, Unick JL, Pellegrini CA. Identifying the most effective components of a physical activity intervention for adults with knee replacement: the MOST Energized! study protocol. BMC Musculoskelet Disord. 2026 Mar 18;27(1):356. doi: 10.1186/s12891-026-09734-9. |
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All data will be deposited into Zenodo at either the time of associated publication or the end of the performance period
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| Experimental condition 5 | Experimental | Energize Online Program plus phone coaching, 'Hear From Others' videos, and individualized feedback |
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| Experimental condition 6 | Experimental | Energize Online Program plus phone coaching and 'Hear From Others' videos |
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| Experimental condition 7 | Experimental | Energize Online Program plus phone coaching and individualized feedback |
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| Experimental condition 8 | Experimental | Energize Online Program plus phone coaching |
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| Experimental condition 9 | Experimental | Energize Online Program plus progress reports to physicians, 'Hear From Others' videos, and individualized feedback |
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| Experimental condition 10 | Experimental | Energize Online Program plus progress reports to physicians and 'Hear From Others' videos |
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| Experimental condition 11 | Experimental | Energize Online Program plus progress reports to physicians and individualized feedback |
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| Experimental condition 12 | Experimental | Energize Online Program plus progress reports to physicians |
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| Experimental condition 13 | Experimental | Energize Online Program plus 'Hear From Others' videos and individualized feedback |
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| Experimental condition 14 | Experimental | Energize Online Program plus 'Hear From Others' videos |
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| Experimental condition 15 | Experimental | Energize Online Program plus individualized feedback |
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| Experimental condition 16 | Experimental | Energize Online Program |
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| Progress reports to providers | Behavioral | Progress reports on physical activity and program adherence will be sent to participants providers at 3 and 6 months. |
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| 'Hear from Others' Videos | Behavioral | Participants will receive monthly 'Hear From Others' videos. The videos will include other adults with knee replacement discussing the challenges they have faced and strategies to overcome barriers to activity. |
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| Individualized Feedback | Behavioral | Participants will receive individualized feedback from a coach via email. The feedback will specifically focus on participant responses to the 'Apply Your Knowledge' activities and will correspond with the video lessons. Feedback will be weekly during months 1-3 and monthly during months 4-6. |
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| Online exercise program | Behavioral | MOST Energized! Online Exercise Program |
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| Baseline to 6 months |
| Pain intensity | Change in pain intensity using Patient-Reported Outcomes Measurement Information System (PROMIS) | Baseline to 12 months |
| Physical Function | Change in physical function using the physical function/mobility Patient-Reported Outcomes Measurement Information System (PROMIS) | Baseline to 12 months |
| ID | Term |
|---|---|
| D009043 | Motor Activity |
| ID | Term |
|---|---|
| D001519 | Behavior |
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