Novel Serum Biomarkers for Identifying Plaque Erosion in ACS and Predicting Prognosis

Development and Validation of Diagnostic and Prognostic Model of Acute Coronary Syndrome Caused by Plaque Erosion Using Novel Serum Biomarkers

The goal of this observational study is to find novel serum biomarkers for the accurate diagnosis of plaque erosion (PE) from acute coronary syndrome (ACS) and help predicting the prognosis of PE. The main question it aims to answer is

• Whether novel serum biomarkers could facilitate the non-invasive diagnosis and prognosis prediction of PE ? Participants will be contacted at 1,2,5 year after the diagnosis of PE-ACS or other reasons of ACS.

Inclusion Criteria:

people presenting with an acute coronary syndrome (ACS)-either non-ST-segment elevation myocardial infarction (NSTE-ACS); or ST-segment elevation myocardial infarction (STE-ACS), and subsequently underwent emergent coronary angiography followed by percutaneous coronary intervention (PCI). Culprit leisions were tested using optical coheren tomograpgy and pathological diagnosis(PE OR PR) were validated by 2 independent experienced core lab members.

Exclusion Criteria:

• patients younger than 18 years or older than 85 years
• patients in cardiogenic shock
• prior coronary artery bypass grafting,
• patients with corornary stent thrombosis
• patients with left main coronary disease
• patients with congestive heart failure
• patients with life-threatening arrhythmia
• patients with thrombocytopenia patients with significant hepatic or renal impairment
• patients with septicemia, leukopenia, active inflammatory or malignant disease
• other factors compromising high-quality optical coherence tomography (OCT) imaging (e.g., severe vessel tortuosity or calcification, persistent no-reflow, lesions in distal segments, or an indeterminate culprit lesion)
• Individuals unable to provide informed consent were also excluded.