fMRI Study of the Neural Mechanism of rTMS in the Treatment of Nicotine Dependence

fMRI（Functional Magnetic Resonance Imaging,fMRI ) Study of the Neural Mechanism of rTMS(Repetitive Transcranial Magnetic Stimulation,rTMS) Stimulation of the Left Dorsolateral Prefrontal Lobe in the Treatment of Nicotine Dependence

The goal of this clinical trial is to investigate the efficacy of treatment and the efficacy-related neural network mechanisms by stimulating the left dorsolateral prefrontal lobe with rTMS to nicotine dependent.

The main questions it aims to answer are:

• Efficacy of left dorsolateral prefrontal rTMS in the treatment of nicotine dependent subjects.
• The relationship between therapeutic effect and the internal function of the large brain networks of ECN, DMN and SN, and the changes in the interaction between the networks.

Participants will randomly divided into two groups，Relevant psychological and behavioral data and fMRI data were collected first, and then rTMS was continuously treated for 2 weeks. The above data were collected again after the treatment ended, and then the follow-up was conducted for 1 month. Psychobehavioral data were collected once a week for nicotine addicts.Finally, the collected neuroimage data were analyzed to compare the difference in efficacy between the true and false treatment groups, and to clarify the relationship between the efficacy of nicotine dependent patients after rTMS treatment and the internal functions of the large brain networks of ECN, DMN and SN as well as the interaction characteristics of the networks, so as to provide a scientific basis for the development of effective individualized treatment programs.

Inclusion Criteria:

• Meets the DSM-V diagnostic criteria for addiction
• Pure nicotine dependence
• Did not receive medication
• Right-handed

Exclusion Criteria:

• Patients with organic brain lesions and a history of severe head trauma
• Compliance is poor
• Multiple drug abusers
• Current or past history of mental or neurological disorders
• There was a metallic foreign object in his body
• People with pacemakers