Evaluate the proportion of seronegative auto-immune hepatitis and a possible relationship with the severity of the disease. Criteria of severity will be defined by corticodependance, corticoresistance and a severe form of the disease at diagnosis (cirrhosis or fulminant hepatitis). In case of predominant seronegative forms, other auto-antibodies related to this auto-immue hepatitis will be searched.

Evaluate the proportion of seronegative auto-immune hepatitis and a possible relationship with the severity of the disease. Criteria of severity will be defined by corticodependance, corticoresistance and a severe form of the disease at diagnosis (cirrhosis or fulminant hepatitis). In case of predominant seronegative forms, other auto-antibodies related to this auto-immue hepatitis will be searched.

Patients from the Guadeloupean constitutive center of rare diseases (CCRD Filfoie) and from the Saint-Antoine hospital will be retrospectively analyzed, and new patients will be prospectively followed.

Inclusion Criteria:

• - Any patient over 18 years old

• Patient followed at Hôpital Saint-Antoine or treated for HAI or in Guadeloupe within the framework of the CCRD Filfoie for an acute or chronic AIH under immunosuppressive treatment

• Patient affiliate or beneficiary of a social security scheme

• Free, informed and written consent signed by the patient and the investigator

  o exclusion criteria: - Patient under 18 years old

• Patient not able to give his/her consent

• Viral hepatitis: viruses A to E, Epstein-Barr virus, cytomegalovirus and herpes simplex virus

• Isolated primary biliary cholangitis

• Isolated primary sclerosing cholangitis

• Drug-induced liver injury

• Wilson disease

• Alcoholic hepatitis

• Hemochromatosis

• Sickle cell disease and heart liver

• Non-alcoholic steato-hepatitis

only acute or chronic AIH patients will be included in the study.