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Literature review showed that there are no studies on the use of i-PRF in alveolitis cases. The aim of this study was to investigate the effect of i-PRF on the treatment of alveolitis. The hypothesis of the study was that i-PRF applied to alveolitis patients would reduce pain.
The present study will include 60 healthy patients over 18 years of age with alveolitis. 60 patients will be randomly divided into two groups: Control and I-PRF. After irrigation of the sockets, no substance will be applied to the control group, and I-PRF will be applied to the study group. Postoperative pain will be measured on the 3rd and 7th days.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| I-PRF | Experimental | I-PRF Application |
|
| Standard treatment | Active Comparator | standard treatment |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| I-PRF | Device | After local anesthesia is injected, alveolar curettage is performed and the socket is irrigated with saline solution. I-PRF is given to patients in the experimental group. |
| Measure | Description | Time Frame |
|---|---|---|
| Change in post-operative pain assessed: visual analog (VAS) scale | VAS measured on a 10cm scale, where 0 represents no pain and 10 represents maximum pain | postoperative 3rd, and 7th days |
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Inclusion Criteria:
Healthy individuals without systemic disease Patients with complete data and attending their appointments
Exclusion Criteria:
Patients who smoke Pregnant or breastfeeding female patients with bleeding disorders and diabetics Patients currently or previously using bisphosphonates or receiving radiotherapy to the jaw Patients unable to consent to participate in the study
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| Name | Affiliation | Role |
|---|---|---|
| Görkem TEKİN, Assist.Prof. | Eskişehir Osmangazi University Faculty of Dentistry | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Eskişehir Osmangazi University | Eskişehir | 26480 | Turkey (Türkiye) |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 38619256 | Result | Uranbey O, Ayranci F. How effective are concentrated growth factor and injectable platelets in reducing complications following impacted third molar surgery? Quintessence Int. 2024 May 30;55(5):380-390. doi: 10.3290/j.qi.b5213477. | |
| 39337554 | Result | Laforgia A, Inchingolo AD, Riccaldo L, Avantario P, Buongiorno S, Malcangi G, Bordea IR, Palermo A, Inchingolo F, Inchingolo AM, Dipalma G. The Use of Platelet-Rich Fibrin (PRF) in the Management of Dry Socket: A Systematic Review. Int J Mol Sci. 2024 Sep 19;25(18):10069. doi: 10.3390/ijms251810069. |
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IPD may share with other researchers upon request
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| ID | Term |
|---|---|
| D004368 | Dry Socket |
| D010146 | Pain |
| ID | Term |
|---|---|
| D009059 | Mouth Diseases |
| D009057 | Stomatognathic Diseases |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
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| Control | Other | After local anesthesia is injected, alveolar curettage is performed and the socket is irrigated with saline solution. |
|
| 29279679 | Result | Sharma A, Aggarwal N, Rastogi S, Choudhury R, Tripathi S. Effectiveness of platelet-rich fibrin in the management of pain and delayed wound healing associated with established alveolar osteitis (dry socket). Eur J Dent. 2017 Oct-Dec;11(4):508-513. doi: 10.4103/ejd.ejd_346_16. |
| 40420265 | Derived | Tekin G, Turedi SO. Is injectable platelet-rich fibrin really effective in alveolar osteitis? a randomised controlled clinical trial. BMC Oral Health. 2025 May 26;25(1):804. doi: 10.1186/s12903-025-06257-y. |
| D013568 |
| Pathological Conditions, Signs and Symptoms |