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| Name | Class |
|---|---|
| Azienda Ospedaliera Universitaria Integrata Verona | OTHER |
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The management of pharmacotherapy in elderly patients is an increasingly critical aspect, as polypharmacy, combined with the pharmacokinetic and pharmacodynamic changes typical of aging, makes older adults more sensitive to the development of adverse reactions. This highlights the importance of appropriate use of pharmacotherapy that considers the risks and benefits of individual treatments. The aim of this study is to measure the prevalence of pharmacological appropriateness using the STOPP/START criteria (version 2) at admission and discharge from an acute geriatric ward, thereby evaluating the impact of hospitalization on medication prescribing.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| STOPP/START Team | Patients over 70 years old admitted to a geriatric ward, regardless of ethnicity, gender, or type of illness, will be considered eligible for enrollment. Patients transferred from another ward or admitted on a support basis to another ward will also be considered eligible. |
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| Measure | Description | Time Frame |
|---|---|---|
| Prevalence of inappropriate prescribing in elderly patients at admission to an acute care hospital using STOPP/START criteria | The analysis of inappropriate prescriptions at admission "Day 0" will be evaluated as a single outcome measure by aggregating data using the STOPP/START criteria. Specific assessments will be reported separately, as they involve different types of information and units of measure:
| Data collected at time Day 0 is analyzed by day 4. Data collected at time Day 1 is analyzed by day 4 |
| Measure | Description | Time Frame |
|---|---|---|
| Prevalence of inappropriate prescribing in elderly patients at discharge from an acute care hospital using STOPP/START criteria. | This analysis focuses on the prevalence of inappropriate prescriptions at discharge "Day 1", defined according to adherence to or deviation from the recommendations specified in the STOPP/START criteria. -Prevalence of Inappropriate Prescriptions (%): The proportion of patients with prescriptions deviating from the STOPP/START criteria. -Destination After Discharge: Categorical variable (e.g., home alone, home with assistance, nursing home, rehabilitation unit).
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Inclusion Criteria:
Exclusion Criteria:
• Patients in the terminal phase (<6 months life expectancy)
Criteria for exit from the study (Dropout):
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Patients aged ≥ 70 years admitted to a geriatric ward, regardless of ethnicity, gender, or type of illness, will also be considered eligible for enrollment.
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| Name | Affiliation | Role |
|---|---|---|
| Luca Pellizzari Dr. Pellizzari, DR | Regione del Veneto - AULSS n. 7 Pedemontana | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Regione del Veneto - AULSS n. 7 Pedemontana | Santorso | Vicenza | 36014 | Italy |
IPD must be submitted to local Ethical Committee
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| Data collected at time Day 0 is analyzed by day 4. Data collected at time Day 1 is analyzed by day 4 |
| Percentage of cases in which inappropriate prescribing will be detected at admission and discharge | Percentage of cases in which inappropriate prescriptions are identified at the time of admission "Day 0" and discharge "Day 1" for each of the individual STOPP/START criteria, i.e., for each of its recommendations. | Data collected at time Day 0 is analyzed by day 4. Data collected at time Day 1 is analyzed by day 4 |
| Association between the prevalence of inappropriate prescriptions and clinical variables, measured using univariate and multivariate regression. | The association between the prevalence of inappropriate prescriptions at the time of admission "Day 0" and discharge "Day 1" and clinical variables of interest (such as place of origin, level of care, comorbidities, polypharmacy, and multidimensional geriatric assessment) was analyzed using univariate and multivariate regression. The univariate regression explored the association of each variable with the prevalence of inappropriate prescriptions, while the multivariate regression was used to estimate the simultaneous effect of multiple variables, controlling for potential confounding factors. | Data collected at time Day 0 is analyzed by day 4. Data collected at time Day 1 is analyzed by day 4 |