AN INTERVENTIONAL, OPEN-LABEL, RANDOMIZED, MULTICENTER PHASE 3 STUDY OF PF-07220060 PLUS LETROZOLE COMPARED TO CDK4/6 INHIBITOR PLUS LETROZOLE IN PARTICIPANTS OVER 18 YEARS OF AGE WITH HORMONE RECEPTOR (HR)-POSITIVE, HER2-NEGATIVE ADVANCED/METASTATIC BREAST CANCER WHO HAVE NOT RECEIVED ANY PRIOR SYSTEMIC ANTICANCER TREATMENT FOR ADVANCED/METASTATIC DISEASE (FOURLIGHT-3)
AN INTERVENTIONAL, OPEN-LABEL, RANDOMIZED, MULTICENTER PHASE 3 STUDY OF PF-07220060 PLUS LETROZOLE COMPARED TO CDK4/6 INHIBITOR PLUS LETROZOLE IN PARTICIPANTS OVER 18 YEARS OF AGE WITH HORMONE RECEPTOR (HR)-POSITIVE, HER2-NEGATIVE ADVANCED/METASTATIC BREAST CANCER WHO HAVE NOT RECEIVED ANY PRIOR SYSTEMIC ANTICANCER TREATMENT FOR ADVANCED/METASTATIC DISEASE (FOURLIGHT-3)
The purpose of this study is to determine the safety and efficacy of PF-07220060 with letrozole compared to approved treatments (ie, palbociclib, ribociclib or abemaciclib with letrozole) in people with breast cancer:
Approximately half of the participants will receive PF-07220060 plus letrozole while the other half of participants will receive the investigator's choice of treatment plus letrozole.
The study team will monitor how each participant is doing with the study treatment during regular visits at the study clinic.
Inclusion Criteria:
Exclusion Criteria:
Beverly Hills, California 90211, United States
Duarte, California 91010, United States
Fremont, California 94538, United States
Fresno, California 93710, United States
Los Alamitos, California 90720, United States
Los Angeles, California 90048, United States
Newport Beach, California 92663, United States
Sacramento, California 95817, United States
San Francisco, California 94158, United States
Grand Junction, Colorado 81501, United States
Elmhurst, Illinois 60126, United States
New Lenox, Illinois 60451, United States
Orland Park, Illinois 60462, United States
Minneapolis, Minnesota 55407, United States
St Louis, Missouri 63110, United States
Mineola, New York 11501, United States
Mineola, New York 11501, United States
Hillsborough, North Carolina 27278, United States
Columbus, Ohio 43210, United States
Portland, Oregon 97213, United States
Tyler, Texas 75701, United States
Tyler, Texas 75708, United States
Madison, Wisconsin 53718, United States
Madison, Wisconsin 53792, United States
CABA, Buenos Aires C1015ABO, Argentina
Passo Fundo, Rio Grande do Sul 99010-080, Brazil
Wuhan, Hubei 430030, China
Nanjing, Jiangsu 210031, China
Helsinki, Uusimaa 00029, Finland
Bordeaux, Aquitaine 33076, France
Rennes, Ille-et-vilaine 35042, France
Rouen, Seine-maritime 76038, France
Ravensburg, Baden-Wurttemberg 88212, Germany
Dresden, Saxony 01307, Germany
Dresden, 01307, Germany
Miskolc, Borsod-Abauj Zemplen county 3526, Hungary
New Delhi, National Capital Territory of Delhi 110085, India
Ramat Gan, Central District 5265601, Israel
Haifa, Northern District 3109601, Israel
Bologna, Emilia-Romagna 40138, Italy
Meldola(FC), Emilia-Romagna 47014, Italy
Rome, Lazio 00168, Italy
Otashi, Gunma 373-8550, Japan
Sakyo-ku, Kyoto 606-8507, Japan
Bunkyo-ku, Tokyo 113-8431, Japan
Chuo-ku, Tokyo 104-0045, Japan
Koto-ku, Tokyo 135-8550, Japan
Shinagawa, Tokyo 142-8666, Japan
Krakow, Lesser Poland Voivodeship 30-348, Poland
Bialystok, Podlaskie Voivodeship 15-027, Poland
Koszalin, West Pomeranian Voivodeship 75-581, Poland
Gangnam-gu, Seoul-teukbyeolsi [seoul] 06273, South Korea
Seoul, Seoul-teukbyeolsi [seoul] 03722, South Korea
Seoul, Seoul-teukbyeolsi [seoul] 06591, South Korea
L'Hospitalet de Llobregat, Barcelona [barcelona] 08908, Spain
Istanbul, İ̇stanbul 34722, Turkey (Türkiye)
Ankara, 06200, Turkey (Türkiye)