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The aim was to examine the effectiveness of hypochlorous acid on postoperative wound healing in 24 systemically healthy gingivectomy participants aged 12-30. The participants were divided into 3 groups as hypochlorous acid group, chlorhexidine group and saline group and their wound healing was evaluated on the 1st, 3rd and 7th days.
The aim of this study was to investigate the effectiveness of hypochlorous acid on postoperative wound healing in 24 participants aged 12-30 who underwent gingivectomy involving the 6 anterior teeth of the upper or lower jaw with chronic inflammatory gingival overgrowth. The participants were divided into 3 groups as hypochlorous acid group, chlorhexidine group and saline group and were called for control on the 1st, 3rd and 7th days to evaluate wound healing. Periodontal indexes, visual analog scale (VAS), H2O2, plaque staining agent test, and histological analyzes were used to evaluate wound healing. The data were analyzed statistically.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Hypochlorous Group | Experimental | In the hypochlorous acid group, 15 ml was used as a postoperative gargle, 2 times * 7 days. |
|
| Chlorhexidine Group | Active Comparator | In the clorhexidine group, 15 ml was used as a postoperative gargle, 2 times * 7 days. |
|
| Saline Group | Placebo Comparator | In the saline group, 15 ml was used as a postoperative gargle, 2 times * 7 days. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Hypochlorous acid | Drug | Hypochlorous acid, chlorhexidine and saline groups were compared as postoperative gargles after gingivectomy surgery. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Plaque index | The amount of plaque was scored. | Baseline, Day 7 |
| Gingival index | The gingival status was scored. | Baseline, Day 7 |
| Probing depth | The periodontal pocket depth was performed (mm). | Baseline, Day 7 |
| Clinical attachment level | The clinical attachment level was measured (mm). | Baseline, Day 7 |
| Bleeding on probing | The gingival status was scored.(%) | Baseline, Day 7 |
| Epithelialization with plaque staining agent | The wound surface epithelialization was observed with plaque staining agent. The wound surface was stained with plaque staining dye and the dark colored area is calculated as mm2. | Day 1, 3, and 7 |
| Epithelialization with H2O2 | The wound surface epithelialization was observed with H2O2. Scored as foaming present/absent after application with H2O2 | Day 3 and 7 |
| Histological analysis | Histological analysis evaluated epithelial keratinization, regeneration, and/or degeneration during the healing process and to obtain epithelial samples repeatedly. The number of keratinocytes was counted. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Sema Nur Sevinç Gül, Dr. | Ataturk University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Atatürk University Faculty of Dentistry | Erzurum | 25240 | Turkey (Türkiye) |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 35578822 | Background | Burian EA, Sabah L, Kirketerp-Moller K, Gundersen G, Agren MS. Effect of Stabilized Hypochlorous Acid on Re-epithelialization and Bacterial Bioburden in Acute Wounds: A Randomized Controlled Trial in Healthy Volunteers. Acta Derm Venereol. 2022 May 31;102:adv00727. doi: 10.2340/actadv.v102.1624. |
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| ID | Term |
|---|---|
| D019214 | Gingival Overgrowth |
| ID | Term |
|---|---|
| D005882 | Gingival Diseases |
| D010510 | Periodontal Diseases |
| D009059 | Mouth Diseases |
| D009057 | Stomatognathic Diseases |
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| ID | Term |
|---|---|
| D006997 | Hypochlorous Acid |
| ID | Term |
|---|---|
| D000148 | Acids, Noncarboxylic |
| D000143 | Acids |
| D007287 | Inorganic Chemicals |
| D017606 | Chlorine Compounds |
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The study included 24 systemically healthy individuals who were randomly divided into three groups: 1) Hypochlorous acid, 2) Chlorhexidine, and 3) Saline.
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| Day 1, 3, and 7 |
| postoperative pain with Visiual Analogue Scale (VAS) | VAS scores were taken on the 3rd and 7th days without any intervention to the patient. Scored between 1-10 as 1 was no pain, 10 was pain. | Day 3 and 7 |
| D017382 |
| Reactive Oxygen Species |
| D005609 | Free Radicals |
| D010087 | Oxides |
| D017601 | Oxygen Compounds |