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pulmonary complications are common in sickle cell disease patients. Respiratory training using inspiratory muscle trainer (IMT) is usually a good choice to improve these complications. Recently, acupuncture like transcutaneous electrical nerve stimulation (AC-tens) may also improve these complications.
sickle cell disease patients whose number will be forty patients will be divided to group I who will trained with IMT (threshold inspiratory muscle training) and treated with AC-tens (the number of patients will be 20) or group II who will trained with IMT (the number of patients will be 20) . The number of sessions per week will be three sessions for IMT or AC-tens for 12 weeks. the IMT will be performed for six sets of respiratory training cycles and the set will contain 10 respiratory cycles. Also the session of AC-tens will be 45 minute on bilateral Ex-B1 acupoint. the parameters of AC-tens will be four hertz and 200 microsecond pulse duration.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| group I | Experimental | sickle cell disease patients whose number will be 20 patients will be trained with IMT (threshold inspiratory muscle training) and treated with AC-tens. The number of sessions per week will be three sessions for IMT or AC-tens for 12 weeks. the IMT will be performed for six sets of respiratory training cycles and the set will contain 10 respiratory cycles. Also the session of AC-tens will be 45 minute on bilateral Ex-B1 acupoint. the parameters of AC-tens will be four hertz and 200 microsecond pulse duration. |
|
| Group II | Active Comparator | sickle cell disease patients whose number will be 20 patients who will trained with IMT (threshold inspiratory muscle training). The number of sessions per week will be three sessions for IMT for 12 weeks. the IMT will be performed for six sets of respiratory training cycles and the set will contain 10 respiratory cycles. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| inspiratory muscle training and acupucnture like transcutanoeus electrical nerve stimulation | Behavioral | sickle cell disease patients whose number will be 20 patients will be trained with IMT (threshold inspiratory muscle training) and treated with AC-tens. The number of sessions per week will be three sessions for IMT or AC-tens for 12 weeks. the IMT will be performed for six sets of respiratory training cycles and the set will contain 10 respiratory cycles. Also the session of AC-tens will be 45 minute on bilateral Ex-B1 acupoint. the parameters of AC-tens will be four hertz and 200 microsecond pulse duration. |
| Measure | Description | Time Frame |
|---|---|---|
| FEV1/FVC ratio | will be measured by spirometry | it will be assessed after12 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| forced expiratory volume at the first second of expiration | will be measured by spirometry | it will be assessed after12 weeks |
| forced vital capacity | will be measured by spirometry |
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Inclusion Criteria:
Exclusion Criteria:
based on self-representation of gender identity.
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Ali Isamil, Lecturer | Contact | 0201005154209 | ali.mohamed@pt.cu.edu.eg | |
| ali ismail, Lecturer | Contact | 0201005154209 | ali.mohamed@pt.cu.edu.eg |
| Name | Affiliation | Role |
|---|---|---|
| Ali Ismail, lecturer | Cairo University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| faculty of physical therapy Cairo university | Recruiting | Dokki | Giza Governorate | Egypt |
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| ID | Term |
|---|---|
| D000755 | Anemia, Sickle Cell |
| ID | Term |
|---|---|
| D000745 | Anemia, Hemolytic, Congenital |
| D000743 | Anemia, Hemolytic |
| D000740 | Anemia |
| D006402 | Hematologic Diseases |
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|
| inspiratory muscle training | Behavioral | sickle cell disease patients whose number will be 20 patients who will trained with IMT (threshold inspiratory muscle training). The number of sessions per week will be three sessions for IMT for 12 weeks. the IMT will be performed for six sets of respiratory training cycles and the set will contain 10 respiratory cycles. |
|
| it will be assessed after12 weeks |
| six minute walk distance | it will be a measure of physical capacity | it will be assessed after12 weeks |
| physical summary of short form 36 | it is a questionnaire measure of quality of life | it will be assessed after12 weeks |
| mental summary of short form 36 | it is a questionnaire measure of quality of life | it will be assessed after12 weeks |
| right diaphragmatic excrusion | it will be assessed by ultrasonography | it will be measured after 12 weeks |
| left diaphragmatic excrusion | it will be assessed by ultrasonography | it will be measured after 12 weeks |
| D006425 |
| Hemic and Lymphatic Diseases |
| D006453 | Hemoglobinopathies |
| D030342 | Genetic Diseases, Inborn |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |