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60 patients aged 65 and older with ASA I-III physical status undergoing elective surgery under spinal anesthesia will be included in the study.
Patients with cardiac arrhythmia, severe heart failure, cerebrovascular disease, or contraindications to neuraxial anesthesia will be excluded. Frailty assessments will be performed using the Clinical Frailty Scale (CFS) version 2.0 by anesthesiologists in preoperative clinics or wards. Participants will be categorized into frail (CFS Level ≥4, Group I) and non-frail (CFS Level ≤3, Group II) groups.
Prior to spinal anesthesia, 8 mL/kg of crystalloids will be administered. Baseline preoperative mean arterial blood pressure (MABP) and heart rate (HR) will be recorded as the average of three measurements in the supine position.
During the study, MABP and HR will be monitored every 2 minutes for the first 20 minutes post-spinal anesthesia, then every 5 minutes until surgery ends. Hypotension (MABP <80% of baseline) will be treated with 5 mg intravenous ephedrine, while bradycardia (HR <50 beats/min) will be treated with 0.5 mg intravenous atropine.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Frail | CFS Level ≥4 | ||
| Non-frail | CFS Level ≤3 |
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| Measure | Description | Time Frame |
|---|---|---|
| Rate of Hypotension | Hypotension, defined as MABP below 80% of baseline values | Preoperative baseline, every 2 minutes for the first 20 minutes, and then at 5-minute intervals until the completion of the surgery. |
| Measure | Description | Time Frame |
|---|---|---|
| Rate of Bradycardia | Bradycardia defined as HR <50 beats/min | Preoperative baseline, every 2 minutes for the first 20 minutes, and then at 5-minute intervals until the completion of the surgery. |
| Ephedrine usage |
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Inclusion Criteria:
Exclusion Criteria:
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Male and female patients aged 65 and over
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| ID | Term |
|---|---|
| D000073496 | Frailty |
| ID | Term |
|---|---|
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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Necessary use of ephedrine (mg) for patients who develop hypotension
| During the procedure |
| Rate of Nausea and vomiting | Nausea and vomiting Visual analogue scale | up to 24 hours |