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| Name | Class |
|---|---|
| Nishtar Medical University | OTHER |
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Asthma affects around 260 million people globally, causing around 0.5 million deaths annually. Pediatric asthma remains a major global public health challenge, significantly affecting the quality of life for many children. Therefore, this study was planned to compare the effects of continuous versus intermittent nebulization of salbutamol in the treatment of acute severe asthma (ASA) in children visiting the emergency department of a tertiary childcare hospital in South Punjab, Pakistan.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Continuous Nebulization of Salbutamol | Experimental | The patients received continuous nebulization of salbutamol at a concentration of 0.3 mg/kg/hour for 4 hours, with a minimum of 5 mg/hour and a maximum of 15 mg/hour administered via high-output extended aerosol respiratory therapy (HEART). |
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| Intermittent Nebulization of Salbutamol | Experimental | The patients were treated with intermittent nebulization of salbutamol at a dose of 0.15 mg/kg/dose, administered through a face mask with an oxygen flow rate of 6-8 L per minute. They received at least 2-3 nebulizations and no more than 7.5 mg/dose every 30 minutes for 4 hours. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Continuous Nebulization of Salbutamol | Drug | Children received continuous nebulization of salbutamol at a concentration of 0.3 mg/kg/hour for 4 hours, with a minimum of 5 mg/hour and a maximum of 15 mg/hour administered via High Output Extended Aerosol Respiratory Therapy (HEART). |
| Measure | Description | Time Frame |
|---|---|---|
| Discharge | When patients met the clinical criteria for discharge, which were an asthma score of 5 or less and a saturation level of over 94% on room air. | 4 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Hospital stay | The length of stay in the hospital was calculated from admission to discharge. | 24 hours |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Arif Zulqarnain, FCPS | Children's Hospital and institute of Child Health Multan, Punjab, Pakistan | Study Director |
| Muhammad Salman, FCPS | Children's Hospital and institute of Child Health Multan, Punjab, Pakistan | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Nishtar Hospital | Multan | Punjab Province | 66000 | Pakistan | ||
| The Children's Hospital and The Institute of Child Health |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41737184 | Derived | Zulqarnain A, Fayyaz A, Zafar S, Fatima B. Continuous versus intermittent nebulization of salbutamol in acute Severe asthma in children under 12 years of age. Pak J Med Sci. 2026 Jan;42(1):185-190. doi: 10.12669/pjms.42.1.11935. |
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| Intermittent Nebulization of Salbutamol | Drug | were treated with intermittent nebulization of salbutamol at a dose of 0.15 mg/kg/dose, administered through a face mask with an oxygen flow rate of 6-8 L per minute. They Children received at least 2-3 nebulizations and no more than 7.5 mg/dose every 30 minutes for 4 hours. |
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| Multan |
| Punjab Province |
| 66000 |
| Pakistan |