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| Name | Class |
|---|---|
| Chinese Academy of Medical Sciences, Fuwai Hospital | OTHER |
| Jianghan University Affiliated Hospital | UNKNOWN |
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This study is a multicenter, prospective, observational study aimed at investigating the efficacy and safety of triple targeted drug therapy in patients with arterial pulmonary hypertension (PAH) who are not at low risk and are receiving initial treatment. The prognosis of arterial pulmonary hypertension is explored.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Non-low-risk PAH treatment-naive patients |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Endothelin receptor antagonist (ERA) combined with PDE5i/sGC agonist dual therapy prostacyclin drugs | Drug | Endothelin receptor antagonist (ERA) combined with PDE5i/sGC agonist dual therapy prostacyclin drugs Including macitentan sildenafil/tadalafil or riociguat selexipag/epoprostenol. |
| Measure | Description | Time Frame |
|---|---|---|
| Pulmonary Vascular Resistance (PVR) | Up to 3 months |
| Measure | Description | Time Frame |
|---|---|---|
| N terminal pro B type natriuretic peptide (NT-proBNP) | Up to 3 months | |
| 6-minute walking distance | Up to 3 months | |
| mean pulmonary arterial pressure (mPAP) |
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Inclusion Criteria:
Exclusion Criteria:
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Adult patients with arterial pulmonary hypertension
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Guanghai Wang, Prof. | Contact | +86 18553136966 | 224138908@qq.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Respiratory, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, #16766, Jingshi Road, Jinan City, Shandong Province, China | Recruiting | Jinan | Shandong | 250014 |
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|
| Up to 3 months |
| cardiac index (CI) | Up to 3 months |
| WHO Heart Function Classification | Up to 3 months |
| Oxygen Saturation of Mixed Venose Blood (SvO2) | Up to 3 months |
| China |
|
| ID | Term |
|---|---|
| D000081029 | Pulmonary Arterial Hypertension |
| ID | Term |
|---|---|
| D006976 | Hypertension, Pulmonary |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
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| ID | Term |
|---|---|
| D065128 | Endothelin Receptor Antagonists |
| ID | Term |
|---|---|
| D045504 | Molecular Mechanisms of Pharmacological Action |
| D020228 | Pharmacologic Actions |
| D020164 | Chemical Actions and Uses |
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