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The PFA (platelet function analysis) test is prescribed for the exploration of primary hemostasis and the study of platelet-willebrand factor interaction. It is performed using citrated blood, with technical difficulties and frequent alarms that may be linked to the choice of anticoagulant (citrate). It is proposed to compare the results obtained with a conventional citrate tube and a BAPA tube, which is an anticoagulant used in clinical research and which blocks coagulation by another mechanism that would have less impact on blood platelets.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients requiring a PFA test for the diagnosis of Willebrand disease |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Sampling of 3 additional BAPA tubes | Biological | the 3 additional tubes will be taken at the same time as the blood sample taken for the routine PFA test |
|
| Measure | Description | Time Frame |
|---|---|---|
| Occlusion time measurement | Measurement of the occlusion times of the 2 cartridges (collagen/ADP and collagen/epinephrine) with the classic 0.109M citrate tube and the BAPA tube, with any PLC alarms and observation of the stained blood smears. | at baseline |
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Inclusion Criteria:
Exclusion Criteria:
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Patients requiring a PFA test
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Emmanuel De Maistre | Contact | 03 80 29 32 57 | emmanuel.demaistre@chu-dijon.fr |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU Dijon Bourgogne | Recruiting | Dijon | 21000 | France |
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