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| Name | Class |
|---|---|
| Bosch Healthcare Solutions GmbH | INDUSTRY |
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This study investigates the use of fractional exhaled nitric oxide (FeNO) measurement to monitor non-pharmacological therapy during a three-week inpatient rehabilitation programme for asthma patients. It compares FeNO levels (measured three times a day) with clinical parameters and quality of life to analyse daily fluctuations and the acute effect of exercise training on FeNO levels. As FeNO is a non-invasive biomarker of airway inflammation, this study aims to expand its role in therapy monitoring and explore its application in a rehabilitation setting.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Asthmatic patients |
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| Measure | Description | Time Frame |
|---|---|---|
| Fractional Exhaled Nitric Oxide (FeNO) at rest | Measurement of FeNo will be done with the Vivatmo Me device (by Bosch Health Care Solutions GmbH) | From enrollment to the end of rehabilitation at 3 weeks. Daily measurements at 9AM; 1PM; 5PM |
| Fractional Exhaled Nitric Oxide (FeNO) before/after exercise | Measurement of FeNo will be done with the Vivatmo Me device (by Bosch Health Care Solutions GmbH) | From enrollment to the end of rehabilitation at 3 weeks, FeNO measurements will be done before and after a bicycle endurance training |
| Measure | Description | Time Frame |
|---|---|---|
| Asthma control | Assessed by Asthma Control Test (ACT) | On admission and discharge from the 3-week rehabilitation programme |
| Lung function | Forced expiratory flow in 1 second, will be measured by Bodyplethysmography |
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Inclusion Criteria:
Exclusion Criteria:
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Patients will be recruitet at the pulmonary rehabilitation center at the Schön Klinik Berchtesgadener Land in Schönau am Königssee, Germany
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Schön Klinik Berchtesgadener Land | Schönau am Königssee | 83471 | Germany |
The data will be made available upon personal request.
The data will be made available upon personal request.
The data will be made available upon personal request submitting a proposal that describes planned analyses.
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| ID | Term |
|---|---|
| D001249 | Asthma |
| ID | Term |
|---|---|
| D001982 | Bronchial Diseases |
| D012140 | Respiratory Tract Diseases |
| D008173 | Lung Diseases, Obstructive |
| D008171 | Lung Diseases |
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| On admission and discharge from the 3-week rehabilitation programme |
| Eosinophils | Eosinophils will be collected by venous blood sample. Unit: total number of cells per ul blood and percentage | On admission and discharge from the 3-week rehabilitation programme |
| C-reactive protein | C-reactive protein will be collected by venous blood sample. Unit: mg/liter | On admission and discharge from the 3-week rehabilitation programme |
| Immunoglobulin E (IgE) | Immunoglobulin E will be collected by venous blood sample. Unit: ug/liter | On admission and discharge from the 3-week rehabilitation programme |
| 6-minute walk test | This test will be performed according to the described standard of the American Thoracic Society and the European Respiratory Society 2014 | On admission and discharge from the 3-week rehabilitation programme |
| D012130 |
| Respiratory Hypersensitivity |
| D006969 | Hypersensitivity, Immediate |
| D006967 | Hypersensitivity |
| D007154 | Immune System Diseases |