Dapagliflozin Versus Dexamethasone Role in Pre-operative Management of Non- Diabetic Brain Tumor Patients

Comparative Study Between Dapagliflozin Versus Dexamethasone Role in Pre-operative Management of Non- Diabetic Brain Tumor Patients

The aim of the study is to compare between the role of dapagliflozin versus dexamethasone in pre-operative management of non-diabetic glioma patients on levetiracetam as anti-seizure drug.

• This is a randomized, parallel, and controlled study, which will be conducted on pre-operative non-diabetic glioma patients on levetiracetam as anti-seizure drug. * This study will be conducted pending registration at ClinicalTrials.gov.
• All patients will give their written informed consents.
• Data of patients will be confidential.
• Any unexpected risk will be reported to patients and Ethical Committee on time. * Randomization will be carried out based on days on hospital admission.

Inclusion Criteria:

• Males & females.

• Age: between 18 and 75 years old.

• Pre-operative non-diabetic glioma patients on levetiracetam. • Diagnosis will be confirmed by:

  • The initial clinical examination.
  • Magnetic resonance imaging of the brain (MRI) with contrast.

Exclusion Criteria:

• Age: > 75 years old, and <18 years old.
• Breast feeding female. • Pregnant female.
• eGFR< 30 mL/minute/1.73 m2.
• Patients with diabetes mellitus.
• Patients with diabetic ketoacidosis.
• Patients with urinary tract infection.
• Dehydrated patients till normalized.
• Lower limb amputation patients.
• SGLT2 inhibitors hypersensitivity.
• Severe hepatic patients (child-plug score class-c).