Lipoprotein Interactions and Platelet Function in Healthy Individuals and Those With Lipid Disorders

Lipoprotein Functions in Healthy Individuals and Subjects With Lipid Disorders

This study looks at how lipoproteins, which are particles in the blood that transport cholesterol, influence heart and blood vessel health. Beyond just their levels, the way these particles function plays a key role in preventing or contributing to disease. In some conditions, like high cholesterol or diabetes, lipoproteins may not work properly, increasing the risk of clogged arteries and other complications.

The investigators aim to study these changes in people with lipid disorders to better understand their impact on blood health and to find new ways to prevent and treat heart disease.

Traditionally, lipoproteins have been associated with cardiovascular protection, but emerging research indicates that their functionality may be a more critical factor than their levels in evaluating cardiovascular risk. Lipoproteins, such as HDL, LDL, and VLDL, play vital roles in processes like reverse cholesterol transport and demonstrate anti-inflammatory, antioxidative, and antiplatelet properties. However, in conditions like atherosclerosis, diabetes, and dyslipidemia, these lipoproteins often become dysfunctional, and the mechanisms behind this dysfunction remain incompletely understood.

This study aims to thoroughly investigate the pathogenic roles of lipoproteins by examining their structural and functional modifications and their influence on platelet activity in individuals with lipid disorders.

Inclusion Criteria:

• Healthy volunteers
• Abnormalities in lipid panels
• Able to provide informed consent
• Between the age of 18 and 69

Exclusion Criteria:

• Drug or alcohol abuse within 6 months or significant mental/psychological impairment
• Current smokers
• Subjects with known bleeding disorders (for example, hemophilia)
• Subjects requiring regular transfusions for any reason
• No ethnic/racial groups will be excluded