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| Name | Class |
|---|---|
| Florida Biomedical Research Program - Bankhead Coley | UNKNOWN |
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This innovative Multilevel Action Toward Colorectal Cancer (CRC) and Hepatitis C Virus (HCV) Education and Screening (MATCHES) intervention aims to promote concurrent HCV and CRC screening among FQHC patients ages 45-75.
While this is a multi-level intervention study, only information related to the patient-level intervention is being reported for the purposes ClinicalTrials.gov.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Multilevel Action Toward Colorectal Cancer and Hepatitis C Education and Screening (MATCHES) | Experimental | The MATCHES intervention includes three patient-level intervention strategies that will be rolled out in two waves. Patient-level strategies are: 1) a combined education booklet with information about CRC/CRC screening and HCV infections/liver cancer/HCV screening in English or Spanish, 2) access to free stool-based CRC screening, and 3) access to free HCV antibody testing. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| MATCHES | Behavioral | Participants will be asked to complete a survey with specific topics including Hepatitis C (HCV) and Colorectal (CRC) knowledge and health beliefs, screening intentions and demographic characteristics. Participants will be provided with education intervention materials (for example, a booklet) either in-person or via mail, access to free stool-based CRC screening, and access to free HCV screening. Approximately 1-2 weeks after receiving the education materials, participants will be asked to complete a post-intervention survey about the same specific topics (for example, HCV and CRC knowledge, HCV and CRC health beliefs, HCV and CRC screening intentions, healthcare experiences, perceptions of the educational materials) over the phone with a trained study staff. Participants with a positive HCV screening and/or CRC screening result will be navigated to follow-up care as needed. |
| Measure | Description | Time Frame |
|---|---|---|
| Screening Uptake for Hepatitis C Virus (HCV) and Colorectal Cancer (CRC) | Screening Uptake will be measured by the number of participants who complete both CRC and HCV screening documented via Electronic Health Record (EHR) at 12 months post-intervention. | Up to 12 Months |
| Measure | Description | Time Frame |
|---|---|---|
| Screening Completion for Hepatitis C Virus (HCV) | Screening Completion for HCV will be measured by the number of participants who complete HCV Screening at any time during the Study Period. | Up to 41 Months |
| Screening Completion for Colorectal Cancer (CRC) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Carol Boxtha | Contact | 813-745-8963 | Carol.Boxtha@Moffitt.org | |
| Shannon Christy, PhD | Contact |
| Name | Affiliation | Role |
|---|---|---|
| Shannon Christy, PhD | Moffitt Cancer Center | Principal Investigator |
| Clement K. Gwede, PhD, MPH, RN | Moffitt Cancer Center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Moffitt Cancer Center | Recruiting | Tampa | Florida | 33612 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41692274 | Derived | Abdulla R, Boxtha C, Courtney EP, Anyanwu OA, Sutton SK, Chung-Bridges K, Kassaye HG, Philippe E, Mudon KA, Frias E, Parras D, Avrilien N, Friedman M, Turner K, Coronado GD, Champion VL, Tobin JN, Vadaparampil ST, Gwede CK, Christy SM. Multilevel Action Toward Colorectal Cancer and Hepatitis C Education and Screening (MATCHES): Study protocol for a hybrid 1 stepped-wedge multibehavioral randomized trial. Contemp Clin Trials. 2026 Apr;163:108256. doi: 10.1016/j.cct.2026.108256. Epub 2026 Feb 13. |
| Label | URL |
|---|---|
| Moffitt Cancer Center Clinical Trials website | View source |
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| ID | Term |
|---|---|
| D006526 | Hepatitis C |
| D015179 | Colorectal Neoplasms |
| ID | Term |
|---|---|
| D000086982 | Blood-Borne Infections |
| D003141 | Communicable Diseases |
| D007239 | Infections |
| D006525 | Hepatitis, Viral, Human |
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Eligible and enrolled patient participants enrolled in the intervention will receive a theory-informed educational booklet about both Colorectal Cancer (CRC) and Hepatitis C Virus (HCV) screening in English or Spanish, access to free stool-based CRC screening, and access to HCV screening. Implementation outcomes, facilitators, and barriers will be examined.
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Screening Completion for CRC will be measured by the number of participants who complete CRC Screening at any time during the Study Period. |
| Up to 41 Months |
| Screening Test Results for Hepatitis C (HCV) | Screening Test Results will be measured as abnormal vs normal | Up to 41 Months |
| Screening Test Results for Colorectal Cancer (CRC) | Screening Test Results will be measured as abnormal vs normal | Up to 41 Months |
| Completion of repeat CRC Screening | Completion of any repeat CRC Screening will be measured by the number of participants who repeat CRC Screening during the Study interval. | Up to 41 Months |
| D014777 |
| Virus Diseases |
| D018178 | Flaviviridae Infections |
| D012327 | RNA Virus Infections |
| D006505 | Hepatitis |
| D008107 | Liver Diseases |
| D004066 | Digestive System Diseases |
| D007414 | Intestinal Neoplasms |
| D005770 | Gastrointestinal Neoplasms |
| D004067 | Digestive System Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D005767 | Gastrointestinal Diseases |
| D003108 | Colonic Diseases |
| D007410 | Intestinal Diseases |
| D012002 | Rectal Diseases |