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| ID | Type | Description | Link |
|---|---|---|---|
| NCI-2024-04793 | Registry Identifier | CTRP (Clinical Trial Reporting Program) |
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This clinical trial evaluates the impact of Quitting Using Executive Function Strategy Training (QUEST) on quitting smoking (cessation) in homeless young adult smokers with an acquired brain injury (ABI). Over 70% of youth and young adults experiencing homelessness (YYEH) smoke tobacco. More than half of YYEH who smoke have made at least one attempt to quit smoking but few use evidence-based methods to increase success. In addition, 9 out of 10 of these have an acquired brain injury which may have a negative impact on successful smoking cessation. QUEST may help homeless young adult smokers with an ABI quit smoking.
PRIMARY OBJECTIVES:
I. Gather data needed to build QUEST (Quitting Using Executive function Strategy Training), an intervention to help youth and young adults (YYEH) with executive function dysregulation better 1) access evidence-based cessation; 2) adhere to processes of evidence-based treatment; and 3) address stress to prevent relapse.
II. Establish the feasibility of collecting acquired brain injury (ABI) status, and impact data sensitive to change over time (clinical and epigenetic), from YYEH tobacco users in community settings.
EXPLORATORY OBJECTIVE:
I. Determine if 1) executive functioning 2) mild cognitive impairment and 3) epigenetic age & other biomarkers of health risk measures are sensitive to difference by ABI status among YYEH past week combustible tobacco users.
OUTLINE:
Patients receive access to the Ohio Tobacco Quitline, receive nicotine patches, gum, or lozenges for up to 8 weeks. Patients also participate in tobacco cessation counseling sessions for 5 sessions over 8 weeks. Patients additionally undergo cognitive assessment and nasal swab collection on study.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Prevention (QUEST) | Experimental | Patients receive access to the Ohio Tobacco Quitline, receive nicotine patches, gum, or lozenges for up to 8 weeks. Patients also participate in tobacco cessation counseling sessions for 5 sessions over 8 weeks. Patients additionally undergo cognitive assessment and nasal swab collection on study. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Biospecimen Collection | Procedure | Undergo nasal swab collection |
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| Measure | Description | Time Frame |
|---|---|---|
| Rate of executive function difficulties | The number of times participants experience executive function difficulties with adhering to the Quit Line protocol will be recorded via survey questionnaires. | Up to 8 weeks |
| Factors impacting access to evidence-based treatment | All factors reported by participants via survey questionnaires that impacted their ability to access Quit Line treatment will be recorded. | Up to 8 weeks |
| Contact with Quitline | The number of contacts each participant had with the Quit Line throughout the study will be recorded via survey questionnaires. | Up to 8 weeks |
| Use of nicotine replacement therapy | The number of times participants made use of nicotine replacement therapies throughout the length of the study will be recorded via survey questionnaires. | Up to 8 weeks |
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Inclusion Criteria:
18-24 years old
Utilizing STAR House ( a drop-in center for youth and young adults experiencing homelessness) services
Use of combustible tobacco product in the last week
Willing to quit smoking in the next 30 days
Acquired Brain Injury (ABI) (15 youth with and 15 without)
Have access to a phone
Willing to use phone for QuitLine (QL) services
Willing to enroll in Ohio Tobacco Quit Line
Willing to share Ohio Tobacco Quit Line portal data with researchers
Willing to provide biospecimens (exhaled air and nasal samples)
Conversational English skills
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| Name | Affiliation | Role |
|---|---|---|
| Julianna Nemeth, PhD | Ohio State University Comprehensive Cancer Center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ohio State University Comprehensive Cancer Center | Columbus | Ohio | 43210 | United States |
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| Label | URL |
|---|---|
| The Jamesline | View source |
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| Cognitive Assessment | Procedure | Undergo cognitive assessment |
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| Interview | Other | Ancillary studies |
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| Nicotine Replacement | Drug | Given nicotine patches, gum, or lozenges |
|
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| Smoking Cessation Intervention | Behavioral | Receive access to the Ohio Tobacco Quit Line |
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| Survey Administration | Other | Ancillary studies |
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| Tobacco Cessation Counseling | Other | Participate in counseling sessions |
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| ID | Term |
|---|---|
| D013048 | Specimen Handling |
| D000073216 | Mental Status and Dementia Tests |
| D007407 | Interviews as Topic |
| D000095488 | Nicotine Replacement Therapy |
| D000074602 | Smoking Devices |
| ID | Term |
|---|---|
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D008919 | Investigative Techniques |
| D009483 | Neuropsychological Tests |
| D011581 | Psychological Tests |
| D004191 | Behavioral Disciplines and Activities |
| D003625 | Data Collection |
| D004812 | Epidemiologic Methods |
| D017531 | Health Care Evaluation Mechanisms |
| D011787 | Quality of Health Care |
| D017530 | Health Care Quality, Access, and Evaluation |
| D011634 | Public Health |
| D004778 | Environment and Public Health |
| D004358 | Drug Therapy |
| D013812 | Therapeutics |
| D008420 | Manufactured Materials |
| D013676 | Technology, Industry, and Agriculture |
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