The effectiveness of Misight 1 Day Contact Lens in retarding anisometropic progression has not been investigated before. This study is aimed to elucidate the efficacy of Misight 1 Day Contact Lens for anisometropia control.

Inclusion Criteria:

• 8-23 years old children diagnosed with anisometropia and are willing to accept MiSight® 1 Day contact lens wearing treatment.
• No congenital eye diseases or eye diseases such as strabismus and amblyopia.
• Those who have been stated to be willing to participate in the program for at least 24 months and accept various evaluations.

Exclusion Criteria:

• Ocular surface disease( dry eye, keratoconus..)
• Allergy to contact lens
• Received eye surgery before
• The cornea is infected (bacterial, fungal or viral infection).
• Strabismus
• Premature birth

We enroll the clinical patients who was diagnosed with anisometropia (meaning that myopia exceeds 100 degree diopters during the refraction examination, and the difference between the other eye is more than 100 degree diopters). Age limit was 8 to 23 years old. The purpose and process were carefully addressed to the subjects and their guardians who signed an informed consent form before commencing this study.