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This study aimed to assess the effectiveness of Coenzyme Q10 in preventing both acute and chronic pain following thoracoscopic surgery, with a focus on its potential benefits in reducing the incidence and severity of pain.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Coenzyme Q10 | Experimental |
| |
| Placebo | Placebo Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Coenzyme Q10 | Drug | Coenzyme Q10 was administered from admission to one month after discharge at a dose of 200 mg per day (200 mg/qd). |
|
| Measure | Description | Time Frame |
|---|---|---|
| The incidence of chronic postsurgical pain | from the end of surgery to 3 months after surgery |
| Measure | Description | Time Frame |
|---|---|---|
| The incidence of acute postoperative pain with a score ≥4 | Use pain Numeric Rating Scale(NRS) to evaluate the movement-evoked pain score and rest pain score. (NRS scale 0-10, where 0 was no pain, and 10 was the worst possible pain) | from the end of surgery to 6 hours,12 hours, 24 hours , 48 hours and 72 hours after surgery. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Guangyou Duan, ph.D | Contact | (+86)18323376014 | duangy@hospital.cqmu.edu.cn |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Guangyou Duan | Recruiting | Chongqing | Chongqing Municipality | 400010 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41025845 | Derived | Liu J, Li L, Luo L, Wu N, Xu F, Tao C, Chen J, Huang H, Duan G. Effect of coenzyme Q10 on pain prevention after thoracoscopic surgery: study protocol. Pain Manag. 2025 Dec;15(12):889-896. doi: 10.1080/17581869.2025.2567832. Epub 2025 Sep 30. |
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| ID | Term |
|---|---|
| D010149 | Pain, Postoperative |
| ID | Term |
|---|---|
| D011183 | Postoperative Complications |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D010146 | Pain |
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| ID | Term |
|---|---|
| C024989 | coenzyme Q10 |
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| Placebo | Other | The placebo was administered from hospital admission until one month after discharge. |
|
| The severity of acute postoperative pain |
Use pain Numeric Rating Scale(NRS) to evaluate the movement-evoked pain score and rest pain score.(NRS scale 0-10, where 0 was no pain, and 10 was the worst possible pain) |
| from the end of surgery to 6 hours,12 hours, 24 hours , 48 hours and 72 hours after surgery. |
| The severity of chronic postsurgical pain | Use pain Numeric Rating Scale(NRS) to evaluate the movement-evoked pain score and rest pain score.(NRS scale 0-10, where 0 was no pain, and 10 was the worst possible pain) | from the end of surgery to 3 months after surgery |
| The incidence of neuropathic pain | The DN4 questionnaire (Douleur Neuropathique 4) was used to evaluate neuropathic pain. The DN4 is a validated diagnostic tool consisting of 10 items, with scores ranging from 0 to 10. A score of 4 or higher indicates the presence of neuropathic pain. | from the end of surgery to 3 months after surgery |
| The frequency of postoperative rescue analgesic use | from the end of surgery to 6 hours,12 hours, 24 hours , 48 hours and 72 hours after surgery. |
| The dose of analgesic use | from the end of surgery to 6 hours,12 hours, 24 hours and 48 hours after surgery. |
| The quality of recovery score at 3 days Postoperatively | The QoR-15 scale, ranging from 0 to 150 with higher scores indicating better recovery, was used to assess the quality of recovery on postoperative day 3. | from the end of surgery to 3 days. |
| Health related quality of life score at 3 months Postoperatively | The SF-8 scale, with a scoring range of 0 to 100 where higher scores indicate better physical and mental health, was used to evaluate health-related quality of life at 3 months postoperatively. | from the end of surgery to 3 months after surgery. |
| Postoperative length of hospital stay | from end of surgery to about 3 to 7 days after surgery. |
| The incidence of adverse reactions | From admission to 3 month post-discharge |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |