Hormonal Management of Heavy Menstrual Bleeding in Adolescents

Hormonal Management of Heavy Menstrual Bleeding in Adolescents and Young Adults With and Without a Bleeding Disorder: a Prospective Observational Cohort Study

The goal of this study is to evaluate whether hormonal medications (such as contraceptive pill, patch, injectable progestins and hormonal intra-uterine device) have similar efficacy at managing heavy menstrual bleeding in adolescents with a bleeding disorder compared to those without. We also aim to assess the quality of life and hemoglobin and iron levels in this population.

Adolescents with heavy menstrual bleeding and willing to start a hormonal medication to reduce menstrual flow are included. At baseline and during the study period, questionnaires and blood tests are performed. Adolescents with a bleeding disorder are compared to those without. Follow-up is 1 year.

Inclusion Criteria:

• Adolescents and young adults aged < 26yo
• Presenting to the gynecology consultation at HUG
• Diagnosed with heavy menstrual bleeding (PBAC > 100)
• Willing to initiate a hormonal medication to manage heavy menstrual bleeding

Exclusion Criteria:

• Pregnancy or planning to become pregnant during the study period
• Already using hormonal medication for menstrual management and/or contraception
• Known anatomical uterine pathology
• Using anticoagulant or antiaggregant agents